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Health Blog·Published: Jan 5, 2026

Fibromyalgia and Metallothionein Dysfunction

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By Andrew Behrman1 min read

Dr. Purser explains symptoms of Metallothionein dysfunctions and how metal toxicity can cause fibromyalgia. Learn how high serum copper levels cause painful inflammation in muscles, nerves, and joints. Explore the genetic components associated with fibromyalgia. Discover key nutritional supplements that help reduce symptoms of fibromyalgia.

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Original sourceDan Purser MD

MAKE SENSE OF YOUR COPPER RESULTS

Non-ceruloplasmin copper calculator

Use your zinc, total copper, and ceruloplasmin blood results to estimate NCC and the copper:zinc ratio.

Zinc
Total copper
Ceruloplasmin

Copy the units exactly. Use blood results collected together when available; your clinician can help if collection dates or sample types differ.

How this estimate works

This uses the formula in Dr. Purser’s handout: NCC (µg/dL) = total copper (µg/dL) − 3 × ceruloplasmin (mg/dL). NCC percentage = NCC ÷ total copper × 100. Copper:zinc ratio = total copper ÷ zinc, using the same units.

Calculated NCC is an estimate. Test methods and how much copper is bound to ceruloplasmin can affect it. It differs from a direct lab measurement of labile or exchangeable copper. It cannot diagnose fibromyalgia or copper toxicity, or choose treatment for you. Read about the limits of calculated NCC at Mayo Clinic Laboratories ↗

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