Gut health, PEMT & choline
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YouTube·Website publication: Jan 6, 2026

PEMT and connection to choline and glutathione!

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By Andrew Behrman1 min read

One of the most powerful nutrients you’ve never heard of? Phosphatidylcholine. It builds the walls of your cells, protects your gut lining, supports nerve function, and even helps your body make bile. If you have a PEMT gene mutation, your body struggles to make it—and that means gut issues, nerve dysfunction, and chronic inflammation.

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Original sourceDan Purser MD

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YouTube captions · May contain errors · Added Sep 23, 2026

Captions can mishear medical terms, names, and doses. Check the recording for context. Each timestamp opens that moment on YouTube.

22 timestamped passages

0:02

What is one of the most vital substances your body uses but you've never heard of? Phosphatidylcholine. What is phosphotidylcholine? Phosphoyloline is a phospholipid. So let's get into a little bit about what phospholipids are and what they're used for. Phospholipids are the

0:19

molecules that create the barriers the the barriers that separate water within our body. So we have water inside and outside of cells. But what is the barrier that keeps the water on either side? That's phospholipids. Phosphotidylcholine, phosphotidal

0:36

serarene. There are several different ones that our body utilizes to create cellular membranes. With these phospholipids, they create a billayer, which means on the outside they're very hydrophobic, but then on the inside they're very hydrophilic. And this creates a perfect blend of keeping water

0:55

on the outside while allowing water and certain substances to pass through the middle, a semi-perium permeable membrane known as a phospholipid billayer. Why would it be important to supply your body with the materials to continually

1:10

make new cellular membranes? There's one gene that I want to talk about real quick and that's called PEMT. This gene specifically is the gene that deals with the synthesis of phosphotidylcholine in our bodies. If we have a snip or a

1:27

genetic error on our PEMT gene, then we will make much less of phosphotidylcholine in our body. We'll be much less efficient at creating and synthesizing phosphotidylcholine. Dr. Ben Lynch is a fantastic doctor that's educated a lot of people about

1:43

PEMT and the benefits of phosphotidylcholine specifically from sunflower lecithin. Every cell in your body utilizes phosphotidylcholine and other phospholipids to create and give its structure. Uh so not just the outside cellular membrane but all of the

1:59

organels, every single part of the cell, the way it's held together is through phospholipids. The mitochondria is the powerhouse of the cell, right? But what creates the the barrier between the mitochondria and the ribosomes or the nucleus or the other parts of the cell?

2:16

It's the cellular membrane made out of the phospholipid billayer. So fast replicating cells and cells that need to reproduce and and fill up areas quickly such as the intestinal lining of of our intestines, those cells have to

2:32

constantly be replenished. And so if you are low in phosphotidylcholine, you won't be able to replenish those cells fast enough that caused from PMT. Now the problem with that is that it causes major digestive issues as well as affecting your gallbladder and the the

2:49

ability to produce bile and actually protect your intestines from bacteria and other issues. So if your body is not able to keep up with the replication and the creation of new cellular membranes, it's always going to be lagging, always going to be behind and causing major

3:04

major digestional issues. Another interesting thing is the importance of phosphotylcholine in nerve function. Nerves are just like any other cells and they use cellular membranes to hold their structure. And so certain nerves

3:19

even have what's called a myelin sheath. That's a a fatty protective layer around the the axons of a nerve of a neuron that allow for faster electrical impulses to pass through and go quickly so that your nerves and everything fire

3:34

the at quicker rates as they're supposed to. But if you again are lacking certain phospholipids, those reactions in reaction speeds are going to be much much slower, much less efficient. So supplementing yourself with a solid phosphotylcholine and very pure

3:51

phosphotylcholine from you can use phospholipids from soy lecithin but we prefer sunflower leithin as that causes less issues for most people. The cool thing is we use phosphotidylcholine in the liposomes of our products. Now

4:06

liposomes are the exact same structure as our cellular membranes. They're just very very very tiny versions of it. uh little spherical balls versus an entire cell. That's why they work is because it's the exact same materials where these phospholipid billayers come

4:22

together and then they can come and meet up with other membranes, cellular membranes and release the payload right into a a into the cell where it can be used. And so our VARS glutathione uses exactly this technology, a phosphotidal

4:39

choline liposome to deliver reduced glutathione right where your body needs it, where it can be absorbed and used right away. And vars glutathione, glutathione plus phospholip phosphotylcholine is extremely beneficial for all of these gut issues. Glutathione and phosphotylcholine

4:55

together are extremely synergistic for the healing of gut linings and the the addition of helping digestive properties. But sometimes you you need a lot of phosphotidylcholine and that's why we prefer there's a couple different brands that we like. Uh but just make

5:11

sure you find a good quality version of phosphotylcoline that comes from good sources that has a good high potency a lot of amount a lot of it in it. I hope this helps uh understand a little bit about the PEMT gene, why it's important that we look at it because if you have this gene snip, most likely you're going

5:28

to be very deficient in phosphotylcholine. So, if you do have PMT, if you're wondering how to see if you have PMT, get a genetic test done uh and then start taking phosphotylcoline. At the very least, start taking bars glutathione and our other VARS products as this really helps with those cellular

5:44

membranes. But get a good phosphotylcoline. Uh, watch watch these gutt issues really heal up.

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