← Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

FOLR2

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

Folate receptors also appear in immune pathways

Folate receptors also appear in immune pathways

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.

Putting the pieces together

Dr. Purser’s folate notes include FOLR2 as part of the uptake story. The practical teaching is to distinguish nutrient intake, intestinal absorption and cellular transport instead of calling every folate-related result an MTHFR problem. A listed variant does not directly measure folate absorption.

A question to bring to your visit

Are we evaluating low intake, absorption, transport or a separate folate-related condition?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

rs789473rs355300

Names you may see

Folate Receptor 2

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