← Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

GAD1

GAD1 helps your body make GABA, a chemical messenger, from glutamate.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

The glutamate-to-GABA connection

The glutamate-to-GABA connection

Dr. Purser’s course uses GAD/GABA teaching to explain a connection between excitatory and inhibitory signaling. GAD1 encodes an enzyme involved in producing GABA from glutamate. B6, amino-acid findings and the person’s medication history are relevant parts of that discussion.

Putting the pieces together

When you review a GAD1 result, your clinician may also look at B vitamins, magnesium, inositol, amino acids, fatty acids, and antioxidant findings. The gene result does not measure brain chemicals or replace mental health care.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

What changed after each product, caffeine change or medication change, and which current findings support the proposed explanation?

Reading your own results

Bring your original report, current results, health history, and medicines to your visit. This information can help you ask questions, but it cannot diagnose a condition or choose a supplement dose for you.

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

Glutamate Decarboxylase 1