← Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

IL18

IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

An inflammatory signal that connects to interferon gamma

An inflammatory signal that connects to interferon gamma

IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP.

Putting the pieces together

Dr. Purser discusses IL-18 in cardiovascular, diabetes and stroke-related teaching. These are clinical contexts for learning, not diagnoses established by a variant. Vascular risk assessment and actual metabolic measurements remain central to understanding an individual’s risk.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

How do my measured metabolic and cardiovascular risk factors fit this immune discussion?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

IL-18 · Interleukin 18