← Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

IL2RA

IL2RA encodes the alpha chain of the interleukin-2 receptor, also called CD25. It is involved in immune activation and regulatory T-cell biology; a soluble receptor measurement is distinct from a DNA result.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

CD25 and immune-cell activation

CD25 and immune-cell activation

IL2RA encodes the alpha chain of the interleukin-2 receptor, also called CD25. It is involved in immune activation and regulatory T-cell biology; a soluble receptor measurement is distinct from a DNA result.

Putting the pieces together

Dr. Purser includes the IL-2 receptor in his sarcoidosis teaching. The key distinction is between an IL2RA genotype, soluble IL-2 receptor testing and the clinical diagnosis. An elevated marker has to be interpreted in context rather than used alone to label sarcoidosis.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

Which kind of IL-2 receptor result do I have, and what clinical question was it intended to answer?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

CD25 · IL-2 receptor alpha