← Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

NOS3

NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

Nitric oxide and the blood-vessel lining

Nitric oxide and the blood-vessel lining

NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.

Putting the pieces together

Dr. Purser connects NOS3 with cardiovascular function. DDAH1 is a useful neighboring lesson because it helps clear ADMA, a molecule that inhibits nitric oxide synthase. Blood pressure, metabolic health, kidney function and medicines supply the practical clinical context.

A question to bring to your visit

What do my blood pressure and vascular risk factors show, and would this marker change my care?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

Nitric Oxide Synthase 3