THE TEACHING CONNECTION
COX-2 and inflammatory prostaglandins
COX-2 and inflammatory prostaglandins
PTGS2, commonly called COX-2, encodes an enzyme involved in prostaglandin production. Prostaglandins participate in pain, fever and inflammatory signaling.
Putting the pieces together
Dr. Purser’s notes connect COX-2 genetics with responses to anti-inflammatory medicines. A marker does not prove that a COX-2 inhibitor will fail. Medication choice should consider the actual response, cardiovascular and kidney risks, gastrointestinal history and other medicines.
A question to bring to your visit
What has my actual response to anti-inflammatory treatment been, and which risks shape the next choice?
Variant lookup
These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.
Names you may see
COX2 · Cyclooxygenase 2


