Makes an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance.
Also called: Catechol-O-Methyltransferase
Catecholamines and sensit…
CTH helps make cysteine, one of the building blocks your body uses to make glutathione.
Also called: Cystathionine Gamma-Lyase
From homocysteine toward glutathione
Dr. Purser places CTH in the sulfur-handling pathway that connects homocyste…
DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.
Also called: Dihydrofolate Reductase
R…
ESR1 encodes estrogen receptor alpha, which helps cells respond to estrogen. Receptor signaling is different from the amount of estrogen measured in blood.
Also called: Estrogen Receptor 1
Estrogen signaling depends on the receptor
ESR1 enc…
Encodes an enzyme involved in fatty-acid metabolism.
Also called: Fatty Acid Desaturase 1 / D5D
The form of a fatty acid matters
Dr. Purser teaches FADS genes as a conversion pathway. FADS1 participates in a delta-5 desaturase step in fatty…
Encodes an enzyme involved in fatty-acid metabolism.
Also called: Fatty Acid Desaturase 2 / D6D
The form of a fatty acid matters
Dr. Purser teaches FADS genes as a conversion pathway. FADS2 participates in a delta-6 desaturase step in fatty…
FTO is studied in relation to body weight and energy balance. Common variants can contribute to population-level differences in obesity susceptibility, alongside many other genes and environmental factors.
Also called: Fat Mass and Obesity-…
GAD2 helps make GABA, a chemical messenger, from glutamate.
Also called: Glutamate Decarboxylase 2
Another part of the GABA system
GAD2 helps make GABA from glutamate. GAD1 does a related job, but the two genes are different. Check the exac…
GCLC helps make glutathione, an antioxidant your body produces.
Also called: Glutamate-Cysteine Ligase Catalytic Subunit
Making glutathione is a process
Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLC supplies the c…
GCLM helps regulate one of the steps your body uses to make glutathione.
Also called: Glutamate-Cysteine Ligase Modifier Subunit
Making glutathione is a process
Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLM suppli…
GDF5 encodes growth differentiation factor 5, a signaling protein involved in skeletal development, joint formation and cartilage biology. Its name does not mean a SNP measures the ability to build muscle.
Also called: Growth Differentiatio…
GGH encodes gamma-glutamyl hydrolase, which removes glutamate residues from folate compounds. This affects folate handling and helps explain why folate metabolism includes retention and processing as well as intake.
Also called: Gamma-Gluta…
Search looks for your words in titles, descriptions, available articles, learning guides, and video captions when available. The closest matches appear first. Duplicate posts are grouped, with links to other places you can read or watch them. Books, chapters, and reports have topic guides here; the original files and full book text are not available in this encyclopedia. Subscriber posts include a title and public summary; open Substack to read the full post.