Let’s explore “Inclusion body myositis: inflammation and cellular stress”

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, pain and wellbeing.

PURSER WELLNESSWhat Is A Fixed Homocysteine Rate?A conversation with Dr. Purser

Homocysteine is a natural molecule your body makes, but when levels get too high it drives massive inflammation by triggering cytokine release. For some people, genetics or deficiencies cause a “fixed homocysteine rate,” meaning diet and vitamins alone won’t lower it. In those cases, the only real way to balance it is by supporting the pathway that converts homocysteine into glutathione. That’s why reduced, stable glutathione—like VARS Glutathione—is essential, because most products are oxidized and useless by the time you take them. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

PURSER WELLNESSWhat is a low copper diet?A conversation with Dr. Purser

A low copper diet focuses on cutting back foods naturally high in copper—like nuts, seeds, chocolate, avocados, and shellfish—because too much copper can build up in the body when certain genes prevent proper regulation. For people with fibromyalgia, migraines, or chronic inflammation, reducing copper intake while supporting balance with nutrients like zinc, boron, molybdenum, and glutathione can make a dramatic difference in symptoms and overall health. Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

🧬 After 15+ years deep in genetics, Dr. Purser sees two root causes over and over again: 1️⃣ Inflammation 2️⃣ Gut & liver dysfunction. Almost every chronic issue—including fibromyalgia, fatigue, and brain fog—ties back to 17 homocysteine SN

PURSER WELLNESSIs Your Fibromyalgia Affected by High Homocysteine?A conversation with Dr. Purser

🧬 High homocysteine isn’t just a heart problem—it’s a major player in fibromyalgia. If you’ve got fibro symptoms, there’s a good chance your transsulfuration pathway is broken—often due to 17 different SNPs or 12 key nutrient deficiencies. That means your body can’t detox properly or convert homocysteine into glutathione, leading to inflammation, pain, and fatigue. Don’t just chase labs—fix the root cause. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Let’s get into the basics of how glutahtione is CRITICAL to removing inflammation and how that benefits YOU. You need VARS Glutathione as your companion to boost your Master Antioxidant levels.

🔥 Got high homocysteine? It’s not just about heart health—it’s about inflammation. Track your IL-8 (yes, you can test it!), and take enough glutathione to bring it down—sometimes that means 4, 6, even 8 capsules a day. When IL-8 hits zero,

A subscriber post from Purser Wellness on Substack, covering genetics and methylation.

🔥 High homocysteine doesn’t just cause strokes—it can cause widespread inflammation and pain that feels like arthritis. 🧬 Often tied to a B6 deficiency, and the only way to catch it early is through intracellular testing. Don’t wait.

If you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 The fix? Add DIM (like DIM Avail) for estrogen balance and use adenosyl + hydroxy B12 for better absorption. Start with drops or go straight to c