ADIPOQ encodes adiponectin, a hormone released by fat tissue that participates in insulin sensitivity and fat metabolism. Its name often appears in discussions of triglycerides, body composition and metabolic health.
Also called: Adiponecti…
The genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH).
Also called: Adenosylhomocysteinase
Methyl-group use leaves another molecule behind
The genetic-archit…
Encodes diamine oxidase, an enzyme involved in breaking down histamine and other amines. DAO is used here as an enzyme nickname; it is also the official symbol of a different gene.
Also called: DAO, Amine Oxidase, Copper Containing 1, Diami…
… encodes a protein that carries lipids between cells. The familiar APOE e2, e3 and e4 groupings depend on the combination of rs429358 and rs7412, not on either marker read in isolation.
Also called: Apolipoprotein E
Lipid transport and brai…
…Also called: Autophagy-Related 16-Like 1
Cellular recycling meets gut immunity
ATG16L1 is involved in autophagy, a process that helps cells recycle parts. It is studied alongside gut immune function. Your symptoms, family history and actual…
BCO1, also called BCMO1, helps convert beta-carotene from plant foods into retinal, a form used in vitamin A metabolism. Plant carotenoids and preformed vitamin A therefore enter the pathway at different points.
Also called: BCMO1, Beta-Car…
BHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway.
Also called: BHMT08, Betaine-Homocysteine S-Methyltransferase
Another route through the homocysteine map
BHMT is part of…
BRCA1 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding.
Also called: Breast Cancer 1
DNA repair and inherited ca…
BRCA2 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding.
Also called: Breast Cancer 2
DNA repair and inherited ca…
CBS helps move homocysteine into the pathway that supplies building blocks for glutathione.
Also called: Cystathionine Beta-Synthase
From homocysteine toward glutathione
Dr. Purser places CBS in the sulfur-handling pathway that connects hom…
CD14 helps immune cells recognize microbial components, including bacterial lipopolysaccharide, as part of innate immune signaling. This places it upstream of some cytokine responses.
Also called: Cluster of Differentiation 14
How immune ce…
…onvert choline toward betaine, a nutrient involved in the homocysteine pathway.
Also called: Choline Dehydrogenase
Choline can serve more than one purpose
CHDH helps convert choline toward betaine, while PEMT helps make phosphatidylcholine.…
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