…er
Dr. Purser’s notes connect MTHFS with folate support and homocysteine. The useful lesson is that the form of folate matters and that several enzymes connect those forms. Discuss the actual product and response alongside B12 and homocyste…
… classified DNA-repair variant?
Variant IDs in the teaching reference: rs2706347
Where the VARS Triad and MTHFR Daily fit
If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathion…
…iscusses TGF-β in fibrosis and scarring, including selected homocysteine-related contexts. This is a reason to identify the organ and clinical process involved rather than treating every elevated inflammatory marker as the same problem. A c…
…is its cause being established?
Variant IDs in the teaching reference: rs20575
Also called: DR4, Death receptor 4
Where the VARS Triad and MTHFR Daily fit
If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily an…
…issue injury in this situation?
Variant IDs in the teaching reference: rs1131568, rs4894559
Also called: TRAIL
Where the VARS Triad and MTHFR Daily fit
If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and t…
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It looks at the following levels: CMP, Homo…
Can the B vitamins you are taking to support energy and methylation eventually make you feel worse?
In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as:
• 5-MTHF or methylfolate
• Methylcobalamin
• Trimethylglycine, also called TMG
• Multiple overlapping methylation formulas
Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.”
These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered.
In this video, we discuss:
• Why methylation is essential
• How methyl-donor supplements support the body
• Why the right vitamin can become the wrong dose
• Ingredients to look for on your supplement labels
• Why some people may need lower doses or non-methylated forms
• How genetics and intracellular nutrient testing can guide a more personalized plan
At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual.
Learn more or schedule with Purser Wellness:
https://danpursermd.com
Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional.
#Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness
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Your body’s ability to detox depends on one critical pathway—turning homocysteine into glutathione. But for millions with MTHFR or other genetic SNPs, this process is broken, leaving them vulnerable to toxins, inflammation, and cytokine storms. That’s why VARS Glutathione is such a breakthrough: it’s reduced, functional, and proven to lower harmful cytokines like IL-8 and MCP-1, giving your body the detox power it needs. After 15 years of research and real patient results, it’s the only oral glutathione that actually works where it matters—inside your cells.
Everyone talks about MTHFR.
But what if that is only one piece of the puzzle?
MTHFR helps process folate, while MTR helps recycle homocysteine back into methionine with the help of vitamin B12.
Two genes.
Different roles.
One interco
Good questions deserve a deeper conversation.
Purser Wellness Explore is a new space to follow yours - videos, articles, and guided journeys with me.
Start with MTHFR, cytokines, homocysteine, gut health… or whatever thread you’re holding
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