…lergic or eosinophilic pattern?
Variant IDs in the teaching reference: rs2069812, rs334809
Also called: IL-5, Interleukin 5
Where the VARS Triad and MTHFR Daily fit
If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHF…
…s that distinction affect care?
Variant IDs in the teaching reference: rs2228145, rs4845625, rs4537545
Where the VARS Triad and MTHFR Daily fit
If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS …
…des an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate.
Also called:
Folinic acid has its own pr…
…s regulatory elements relevant to the nearby IL4, IL5 and IL13 cluster, so a locus association can concern more than the coding function of one gene.
Also called:
DNA repair and a nearby Th2 regulatory region
RAD50 encodes a DNA-repair pro…
TNFRSF10A encodes death receptor 4, or DR4, a receptor that can receive the TRAIL signal and participate in regulated cell-death pathways. TRAIL itself is encoded by TNFSF10.
Also called:
DR4 receives the TRAIL signal
TNFRSF10A encodes dea…
TNFSF10 encodes TRAIL, a signaling protein involved in regulated cell death through particular receptors. It is a different member of the TNF-related signaling family from TNF itself.
Also called:
TRAIL and regulated cell death
TNFSF10 enc…
…te toward cysteine is called transsulfuration.
Folate and B12 help with one recycling route. Betaine, which can come from choline, helps with another. CBS and CTH carry out the two core steps toward cysteine. These nutrients and enzymes wo…
…d alongside kidney function, nutrition, genetics, and other laboratory findings.
Your lab results are more than numbers on a page.
They are clues that can help you ask better questions about your health.
Learn why kidney health and homoc…
…s can be more complicated than simply looking at a standard lab panel.
A CMA is designed to provide another perspective on how your cells respond to essential nutrients, giving you and your healthcare team additional information to conside…
…e the NLRP3 sensor, inflammasome priming and activation, IL-1 beta, IL-18, and pyroptosis.
Understand the connection
NLRP3 is an intracellular danger sensor, rather than a circulating cytokine. It can assemble an inflammasome, a protein co…
…clinical reality I have mapped in my practice, refined over 12 years of data from thousands of patients, and will soon publish in my 600-page textbook Homocysteine: The 2026 Comprehensive Diagnosis & Treatment Protocol . My work is a decade…
… kidney or blood pressure issues.
Homocysteine isn’t just a lab number — it’s a toxic byproduct that drives inflammation through cytokines like MCP-1 and IL-8, damaging blood vessels and disrupting hormones.
Dr. Purser’s research found up t…
Search looks for your words in titles, descriptions, available articles, learning guides, and video captions when available. The closest matches appear first. Duplicate posts are grouped, with links to other places you can read or watch them. Books, chapters, and reports have topic guides here; the original files and full book text are not available in this encyclopedia. Subscriber posts include a title and public summary; open Substack to read the full post.