Can the B vitamins you are taking to support energy and methylation eventually make you feel worse?
In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as:
• 5-MTHF or methylfolate
• Methylcobalamin
• Trimethylglycine, also called TMG
• Multiple overlapping methylation formulas
Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.”
These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered.
In this video, we discuss:
• Why methylation is essential
• How methyl-donor supplements support the body
• Why the right vitamin can become the wrong dose
• Ingredients to look for on your supplement labels
• Why some people may need lower doses or non-methylated forms
• How genetics and intracellular nutrient testing can guide a more personalized plan
At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual.
Learn more or schedule with Purser Wellness:
https://danpursermd.com
Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional.
#Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness
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What if the key to feeling better isn't another health trend—but understanding the nutrients your body depends on every day?
Vitamin C. B vitamins. Iron.
These essential nutrients influence everything from energy production and immune fun
In this powerful live session, Dr. Dan Purser MD reveals why conventional pediatric medicine often falls short and shares his proven Purser Method® for helping children with autism spectrum traits, severe ADHD, chronic inflammation, and developmental delays.
Drawing from over 43 years of clinical experience, Dr. Purser explains:
Why genetic testing (especially MTHFR and related SNPs) is the essential first step
How to use targeted, active-form nutrients instead of generic vitamins
The role of leucovorin (high-dose folinic acid) and when it makes a real difference
Practical ways to reduce toxin load and calm the inflammatory response
Smart strategies around vaccination and detoxification support
Dr. Purser emphasizes that kids are not little adults — their developing systems need precise, individualized care. Parents and practitioners will walk away with actionable steps that address root causes rather than just managing symptoms.
Whether your child is struggling with speech delays, meltdowns, focus issues, or recurrent health problems, this episode offers real hope through biochemistry done right.
Resources Mentioned:
Pediatric MTHFR formulas: https://www.PhysicianDesigned.com
Book a consultation: http://www.DanPurserMD.com
Dr. Purser’s books on Amazon: https://www.amazon.com/-/e/B00BIKSGVQ
If you’re a parent tired of “there’s nothing more we can do,” or a practitioner looking for better tools, this episode is for you.
Timestamps available in the full video.
Subscribe, leave a review, and share this with any parent who needs to hear it. The kids deserve better answers.
Dan Purser MD – Root Cause Inflammation & Genetic Optimization
#MTHFR #Autism #ADHD #ChildrensHealth #Leucovorin #FunctionalMedicine #Pediatrics
Follow Dr. Purser!
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
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Are you getting enough B6 Pyridoxine? Join Dr. Dan Purser MD and Purser Wellness Coach Jackson Larkin as they dive into the science behind Pyridoxine and why it’s essential for your energy, mood, and overall health. Discover how B6 can help
Unlock the power of B1 Thiamine! Join Dr. Dan Purser MD and Purser Wellness Coach Jackson Larkin as they reveal how this essential vitamin can boost your energy, support your nervous system, and help you feel your best.
Did you know scurvy is still around today? It might sound like an old pirate disease, but a lack of Vitamin C can still cause fatigue, joint pain, bleeding gums, and slow healing. Without Vitamin C, your body can’t make collagen, which is essential for healthy skin, blood vessels, and connective tissues.
High homocysteine levels can lead to inflammation, joint and muscle pain, and even shifting pain throughout the body. It’s also linked to birth defects and chronic kidney failure, and can raise blood pressure. Six genetic SNPs (like MTR, MTRR, and CBS) and MTHFR mutations (like C677T) can prevent homocysteine from converting into glutathione, which is essential for keeping inflammation in check. Plus, 12 vitamin deficiencies may temporarily raise homocysteine levels, so addressing these deficiencies is key.
Do you struggle with osteoporosis or bleeding disorders? Learn why Vitamin K is critical to bone density and prevention of osteoporosis. Discover the relationship of Vitamin K deficiency and bleeding disorders such as borderline hemophilia, joint bleeding disorders, haemarthrosis (bleeding into joint spaces), and how Vitamin K is critical for proper clotting. Explore why Vitamin K2 is essential, and why a combination of fat-soluble Vitamins A, D, and K should be taken together. Learn about contraindication of Vitamin K for patients taking blood thinners. Contact us at (801) 796-7667 or info@da
Copper is one of the body’s most important minerals in your body — a tiny metal with massive impact.
It acts as a cofactor in essential enzymes like SOD1 (superoxide dismutase) that protect your cells from oxidative stress, and even helps
Thyroid health remains essential during menopause. Optimal labs should show FT3 around 4.0 and FT4 near 1.5, and testing through Direct Labs makes it easy to track. Supporting with supplements like Thyromin can help, but only if guided by accurate lab results.
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
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Copper is essential for life—it helps enzymes work, supports SOD1 for antioxidant defense, and even prepares iron to carry oxygen in the blood. But when copper builds up in the bloodstream instead of entering cells, it causes pain, tender points, and migraines. This often ties back to genes like CBS, NAT2, and glutathione-related SNPs that impair copper transport. The solution is supporting ceruloplasmin—the copper-binding protein—with targeted nutrients like B6, zinc, and NAC. That’s why Copper Balance was created: to move copper where it belongs and help symptoms finally improve. Visit PhysicianDesigned.com or Amazon for Copper Balance.
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
Facebook: https://www.facebook.com/danpursermd
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For women who can’t take bioidentical hormones, essential oil–based options like Clary Sage, Progessence Plus, and PD 80/20 offer natural support. These were designed and tested with hormone balance in mind and can help ease the symptoms of low estrogen and progesterone.
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
Facebook: https://www.facebook.com/danpursermd
Facebook: https://www.facebook.com/PhysicianDesigned
Twitter: https://twitter.com/realdanpursermd
YouTube: https://www.youtube.com/danpursermd
Instagram: https://www.instagram.com/danpurser.md
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