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Gene & pathway reference · FROM DR. PURSER’S TEACHING

IL33

IL33 encodes interleukin-33, a signal that can act as an alarmin during tissue stress and promote type 2 immune responses. It belongs in a different functional group from chemokines that recruit cells.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

An alarmin in allergic signaling

An alarmin in allergic signaling

IL33 encodes interleukin-33, a signal that can act as an alarmin during tissue stress and promote type 2 immune responses. It belongs in a different functional group from chemokines that recruit cells.

Putting the pieces together

Dr. Purser connects IL-33 with hay fever and allergic rhinitis and discusses interaction with homocysteine-related oxidative stress. Follow both parts of that model separately: evaluate the allergic pattern and measure the metabolic findings rather than assuming one proves the other.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

Have the allergic triggers and the homocysteine or redox findings each been evaluated?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

IL-33 · Interleukin 33