THE TEACHING CONNECTION
Balancing clot formation and clot breakdown
Balancing clot formation and clot breakdown
SERPINE1 encodes plasminogen activator inhibitor-1, or PAI-1, which helps regulate fibrinolysis: the process that breaks down clots. PAI4G refers to this pathway rather than a separate gene.
Putting the pieces together
Dr. Purser includes PAI-1 in the clotting conversation. Clot formation and clot breakdown are different processes, so a marker must be interpreted alongside personal and family clotting history and other risk factors. It is not a stand-alone reason to take aspirin, anticoagulants or supplements marketed for circulation.
A question to bring to your visit
Does this finding have a validated implication beyond my established clotting risk factors?
Variant lookup
These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.
Names you may see
PAI-1 · PAI4G · Plasminogen Activator Inhibitor-1 · Plasminogen Activator Inhibitor 1, 4G/5G Polymorphism
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
CAPSULES & LIQUID
Glutathione options
Explore supplements Dr. Purser discusses for methylation and antioxidant support.
Choose between capsule and liquid forms with your clinician.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
