THE TEACHING CONNECTION
Recycling vitamin K and responding to warfarin
Recycling vitamin K and responding to warfarin
VKORC1 encodes vitamin K epoxide reductase, part of the vitamin K recycling system used in activating clotting proteins. It is not simply a vitamin K receptor.
Putting the pieces together
Dr. Purser’s notes flag this pathway because it matters to clotting and medication response. Certain variants can alter warfarin dose requirements, including increased sensitivity; they do not generally mean warfarin will not work. Anyone taking warfarin should discuss vitamin K products or substantial dietary changes with the anticoagulation team and continue prescribed INR monitoring.
A question to bring to your visit
Does my pharmacogenetic result affect my warfarin plan, and who is coordinating vitamin K intake and INR checks?
Variant lookup
These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.
Names you may see
Vitamin K Epoxide Reductase Complex Subunit 1
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
SUPPLEMENT OPTIONS
ADK Evail
Dr. Purser discusses these supplements in relation to VKORC1.
Some genetic results may make these options more relevant to you. Review your full genetic report with your clinician before choosing a supplement.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
