How are MTHFR and Fibromyalgia so closely connected? Methylation pathways and the conversion of Homocysteine to Glutathione. These are critical for humans but certain genetic factors make them much less efficient. Help is on the way.
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MAKE SENSE OF YOUR COPPER RESULTS
Use your zinc, total copper, and ceruloplasmin blood results to estimate NCC and the copper:zinc ratio.
This uses the formula in Dr. Purser’s handout: NCC (µg/dL) = total copper (µg/dL) − 3 × ceruloplasmin (mg/dL). NCC percentage = NCC ÷ total copper × 100. Copper:zinc ratio = total copper ÷ zinc, using the same units.
Calculated NCC is an estimate. Test methods and how much copper is bound to ceruloplasmin can affect it. It differs from a direct lab measurement of labile or exchangeable copper. It cannot diagnose fibromyalgia or copper toxicity, or choose treatment for you. Read about the limits of calculated NCC at Mayo Clinic Laboratories ↗
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EXPLORE WITH YOUR CARE TEAM
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
Explore supplements Dr. Purser discusses for methylation and antioxidant support.
COMPARE YOUR OPTIONS
Dr. Purser discusses these supplements in relation to MTHFR.
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your folate, vitamin B12, and genetic results can help your clinician choose between them.
CAPSULES & LIQUID
Choose between capsule and liquid forms with your clinician.
SUPPLEMENT OPTIONS
Ask your clinician how this option fits your results and current medicines.
SUPPLEMENT OPTIONS
Ask your clinician how this option fits your results and current medicines.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
A term in this discussion
Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.
A term in this discussion
Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.
A term in this discussion
No universal wellness target. Ask your clinician to read this result with B12, folate, B6, kidney, thyroid, genetics, and medications.
More on Homocysteine: follow the connections
How Elevated Homocysteine, Impaired Methylation, and Glutathione Deficiency May Be Driving PCOS, Chronic Pain, Brain Fog, Stroke Risk, and Detox Failure — and Why Genetic Testing WILL Change the Way https://danpursermd.substack.com/p/high-homocysteine-mthfr-mutations?utm_source=youtube
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