If you've been tested and already know you have MTG4, how do you know where to start? Get in or vitamin testing. I really don't care what genetic issues you have. Well, I kind of do it, but I mean, you'll care more than I do, obviously. But my job is to get you feeling normal. And those vitamin deficiencies show up in one major way. Usually, it's it
sorry, those genetic snips show up in one major way. I already gave it away. It's vitamin deficiencies. Interested deficiencies. N 99% of them are caused by genetic snips. That's how they damage you. That's how they caused you problems. That's how your ancestors died
early because they got horribly malnourished and died from that genetic stuff. So, say they can't get vitamin testing right now, would it be okay to start on like MTHR renew or MTH? Yeah, if they think they have it. Yeah. Yeah. Like if they know they have MTHR, then those and so if you have like like I saw a lady this week with 29 SNIPS. Oh, good
lord. That broke her record. um she need like two or three are new and like seven to 10 endure a day a day to read that many. That's ridiculous, but it's the way it is. If you want to feel normal and if you um if you have like 13 or 14 uh like your mom had um you need she
took one or two Renew and five or six endure for years. Now she's on like four endure. She finally cut got rid of the Renew. I'm on one endure. Yeah. Mhm. It works and people vary. Yeah, that's exactly the point. It takes time. Yeah. Yeah. Cuz you're compound hetererozygous, right?
I think so. Yeah. And I'm 71. So I take half of a tiny vine, which is a fourth of an in what I take. But but no, taking it felt horrible.
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
COMPARE YOUR OPTIONS
Methylation support
Dr. Purser discusses these supplements in relation to MTHFR.
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your folate, vitamin B12, and genetic results can help your clinician choose between them.
Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.
That afternoon sugar craving may be telling you more than you think. Here’s how methylation, glucose, cellular energy and your genetics may fit into the bigger picture.
https://danpursermd.substack.com/p/mthfr-and-the-never-ending-sugar?utm_source=youtube
MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets
If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.”
In this video, we break down exactly why this happens:
How MTHFR/methylation issues impair ATP (energy) production at the cellular level
Why your body desperately reaches for quick glucose
The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage
The downstream effects on antioxidants, DNA repair, and overall energy
How to finally break the cycle:
Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests)
Why our MTHFR Daily multivitamin was specifically formulated for this
The power of CMA intracellular testing
Intermittent fasting (12–16 hrs)
Fasted cardio (even just a brisk walk)
High-protein, real-food diet with minimal processed sugars
If you’re tired of the sugar rollercoaster and want stable energy, this is for you.
Links:
Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle
Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com
Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily
Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious!
#MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting
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