If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.”
In this video, we break down exactly why this happens:
How MTHFR/methylation issues impair ATP (energy) production at the cellular level
Why your body desperately reaches for quick glucose
The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage
The downstream effects on antioxidants, DNA repair, and overall energy
How to finally break the cycle:
Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests)
Why our MTHFR Daily multivitamin was specifically formulated for this
The power of CMA intracellular testing
Intermittent fasting (12–16 hrs)
Fasted cardio (even just a brisk walk)
High-protein, real-food diet with minimal processed sugars
If you’re tired of the sugar rollercoaster and want stable energy, this is for you.
Links:
Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle
Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com
MTHFR and the neverending sugar crash cycle. You may have seen a recent Substack post of ours. Uh make sure to go follow the personal wellness Substack uh as well as my own Substack if you want to. I do a couple little articles here and there. But one of our latest posts were about was about MTHFR and the whole process
and cycle that happens with sugar ATP production and energy cycles up and down. Really, what that has to come down to is the way that our body processes sugar into the blood and into the cell eventually and where that's actually coming from. [music] So, let's break it
down a little bit. MTHFR, it's a genetic snip. Uh, there's two variants that we like to look at, the C677 and the A1298C. If you've gotten your genetic testing done, hey, let us know which one do you have. Are you hetererozygous homozygous? I'm always super curious to know about that. So, if you have one of
these MTHFR snips, that really has to do with folate uh production, folate manufacturing, folate just the way folate's used throughout our cells, [music] but it's not the end- all beall for everything folate. We're really talking about a widespread of things around methylation issues. And so, when
we talk about MTHFR, it's kind of a broad catch-all term. We're really talking about methylation. And methylation has many different processes all that lead down to DNA production, antioxid antioxidant production, um antioxidant oxidant protection and
energy production. All these different things are kind of downstream effects of MTHFR. So of methylation. So it's a really wide broad widespread term that we use to talk about a lot of different things. But today I want to talk about the cycle that so many of our patients and our clients get into of just dealing
with sugar cravings because of their MTHFR status. When when we deal with sugar um sugar generally the sugar that we're actually looking for is called glucose. Glucose is the version of sugar that our body uses readily readily to create ATP in our cells. And now glucose
isn't the only production the only energy production molecule that we use. We also use stored fats um and even proteins. at certain times and even lactic acid at other times, ketones. We use all these different sources of energy to create ATP in our cells, but
glucose is the quickest is the fastest acting one. And so it's the one that our body jumps to quickest to make energy happen to make to make our cells uh feel satiated and energized so that they can actually continue their their uh functions. So with MTHFR
we are always behind in making ATP just we never make enough energy at an in at an a cellular level at a molecular level. So the different MTH of our variants and Dr. Burkers has talked about this in the past will even cause a varying degree of how many ATP per one
carbohydrate that we can actually create [music] and there's different varying ways to look at that and take that but there's certain MTHFRs that are going to be more intense than others. So again, the overall aspect of what we're talking about is [music]
someone with MTHFR always lagging, always waking up tired every day and just never able to get ahead energy-wise. And so they get put into this cycle. They then their body thinks we just need quick energy now to help fulfill this lack of energy that we're dealing with. And so you go and reach for quick
sugars. And that's where fruits are one thing, probably one of the better carbohydrates you can reach for. Uh but then in our modern world, we actually reach a lot for any processed foods, whatever is quickest and easiest. Just pop it in, feel good, feel great in that moment, and then 20 minutes later, you get an insulin crash, and you don't feel
so good anymore. So, we get this neverending cycle of reach for a quick sugar, you feel great for a minute, insulin spikes, blood sugars are going crazy, and then they just drop. Everything plummets. The other major thing that happens is that your cells
want to use those quick sugars uh more than anything. But then when there's an overabundance because we get into the cycle, eat again and again and again, more of those sugars are then going to become stored fat and glycogen. And so you then are using all these sugars to to have a good quick high, but then
you're storing all the rest of them, increasing the amount of fat that's stored on the body. And so this neverending cycle is just terrible for people. We get stuck in it. I myself have been stuck in it multiple times through my life and you think you're doing everything you can. You're still working out. You're still trying to eat
as good as you can, but you keep grabbing those quick sugars and you just keep getting in this circle back and forth again and again and you just happen to store more and more fat each time. So, what can you do to break this cycle? How do you get out of this? And that's what I love about our MTHFR uh the intracellular testing that we do and
our MTHFR Daily product. [music] Uh we we designed MTHFR daily based off of all of the recent 15 or 20,000 intracellular tests that we got and combined with which ones were MTHFR patients or not. And we made the multivitamin with what everyone was the most deficient in, what
the most amount of people were deficient in. That's what MTHFR daily is. And that's what fills all those holes of methylation. We're not just talking about folate and we're not even just talking about methylated B vitamins. There's a number of nutrients that we're deficient in that are just missing throughout that whole methylation cycle
and that is what is causing your inability to really make that downstream effect of ATP. Everything gets thrown out of whack. So fill the holes of methylation that remember that brick wall we've talked about before. It has a bunch of holes in it. That's your MTHFR status. But if you can supplement with
the correct forms of certain nutrients, you fill each and one of those holes and you have a nice sturdy wall. Once again, that's what we're trying to do with our methylation. When that's all in place, give your body those antioxidants that methylation is trying to produce anyway. And then let your cells do what it's
supposed to do. Blood sugars stabilize. They normalize. And that's why we love getting the CMA intracellular testing because it gives us all the other nutrients that you're deficient in to help really stabilize those blood sugars. So that the correlation of how much sugar is being given into the cells
versus how much leftover for storing into fat, we we help that we help stabilize all that. Now, next, we want to get your body into a place where it's actually needing to use the stored fat, turn that glycogen into glucose for use. And so, there's several steps that you
have to do to get your body into that stage to be able to do that. So, one thing is fasting overnight. Really, really great. Um, even for a solid 12, 16 hours a day, not having anything go through your digestive tract is going to put your body into the stage of where it needs to utilize what it has saved. So
intermittent fasting is incredibly beneficial for that. Number two, um doing cardio during that [music] fasted time is going to be the optimal time for your body to burn that stored fat. Uh because it has to use whatever energy source it can and nice cardio, just a
good quick pace on the treadmill, even add some incline if you can, is going to be the best thing. You're not even running, just walking, doing a nice quick walk. So, take a good long long walk around your neighborhood. Anything is going to be the best thing for you in those early times of the day to do some fasted cardio. Put your body right into
that phase. Now, next is going to be trying to uh remove those processed sugars from your diet. It's going to be the next thing. Give your body the real foods that it needs to be able to remove sugar uh excess sugar floating around in the blood so that it can utilize the
stored fats. So, high protein diet is going to be your best bet for that. Um, get your body into even a keto state here and there. That's where the intermittent fasting, high protein, and just really good simple carbohydrates are going to be the best thing for you to just keep your body chugging along in the ways that it's supposed to alongside
all the supplementation of just like we talked about. Fill all the holes of methylation, fill any other deficiencies you're you're dealing with, watch the whole thing get better. And so that's really kind of the overall aspects of what we have to talk about with MTHFR and the neverending sugar crash cycles
that our patients deal with. So if you have any other questions about this topic, definitely go check out our Substack article, call our office, get that testing done, CMA testing, get your genetic testing done. We are here to help you every step of the way um figure out these complex issues, genetic issues
and deficiency issues that so many of us deal with. You're not alone and we can definitely help you. Thanks.
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
COMPARE YOUR OPTIONS
Methylation support
Dr. Purser discusses these supplements in relation to MTHFR.
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your folate, vitamin B12, and genetic results can help your clinician choose between them.
Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.
That afternoon sugar craving may be telling you more than you think. Here’s how methylation, glucose, cellular energy and your genetics may fit into the bigger picture.
https://danpursermd.substack.com/p/mthfr-and-the-never-ending-sugar?utm_source=youtube