Let’s explore “folate”

…ion. The route toward cysteine is called transsulfuration. Folate and B12 help with one recycling route. Betaine, which can come from choline, helps with another. CBS and CTH carry out the two core steps toward cysteine. These nutrients an…

…bsorption, Intrinsic factor receptor activity, Methylation, Folate metabolism. These are topics to explore, not a diagnosis or a measurement of how the pathway works in your body. Understanding a result A gene name is only a starting point.…

… level is not just about what you eat. Nutrition matters. Folate matters. Vitamin B12 matters. Vitamin B6 matters. Lifestyle matters. Genetics may matter too. So why are we waiting until disease appears before asking what our biology…

…r picture. Variants such as C677T and A1298C can influence folate metabolism and methylation. Stop blaming yourself. Start understanding the biology. Support your nutrition. Support methylation when appropriate. Prioritize protein,…

PURSER WELLNESSUnderstanding Your CMA with Redox Results: What Those Two Pages Actually MeanA conversation with Dr. Purser

…r brain fog? We often see patterns with B vitamins (B12, B9/folate, B7), CoQ10, or amino acids. • Dealing with anxiety or feeling “wired but tired”? A glycine deficiency can impair GABA production — your body’s primary calming neurotransmit…

…THFR gene variants (common in ~85% of people). These impair folate processing → elevated homocysteine → massive inflammation and cytokine storms (IL-6, TNF-α, IL-17, etc.). High homocysteine (>10-12 µmol/L; ideal <7-8) acts like a "cytokin…

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss From the reading room

…gle-nucleotide changes reduce the enzyme methylenetetrahydrofolate reductase activity by 30–70%, impairing the conversion of folate into its active form (5-methyltetrahydrofolate). The downstream result? Impaired methylation, elevated plasm…

…R gene may be part of the reason. MTHFR (Methylenetetrahydrofolate Reductase) is a genetic SNP—a small DNA variation that affects how your body processes folate (vitamin B9). The most common variants, C677T and A1298C, can reduce your abili…

…the root cause: methylation and nutrient deficiencies (B12, folate, B6, and more). High homocysteine isn’t just a number on a test. It’s one of the biggest, most overlooked drivers of PCOS symptoms — and it’s fixable.

…ome don’t matter, but others can throw off key systems like folate metabolism (MTHFR), antioxidant defense (SOD), and glutathione production. While you can’t change your genes, you can support them. At Purser Wellness, we combine genetic an…

…covorin is simply high-dose folinic acid, a natural form of folate. While it may help some children and has even been promoted as a “cure,” it’s only one piece of the puzzle. True protection comes from supporting the body’s entire defense s…

…bout 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying t…