Let’s explore “SLC19A1 & folate transport”

…r picture. Variants such as C677T and A1298C can influence folate metabolism and methylation. Stop blaming yourself. Start understanding the biology. Support your nutrition. Support methylation when appropriate. Prioritize protein,…

…ything from energy production and immune function to oxygen transport and cellular health. Yet many people don't realize how deficiencies, poor absorption, or nutrient imbalances may affect how they feel. The real question isn't whether …

…THFR gene variants (common in ~85% of people). These impair folate processing → elevated homocysteine → massive inflammation and cytokine storms (IL-6, TNF-α, IL-17, etc.). High homocysteine (>10-12 µmol/L; ideal <7-8) acts like a "cytokin…

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss From the reading room

…gle-nucleotide changes reduce the enzyme methylenetetrahydrofolate reductase activity by 30–70%, impairing the conversion of folate into its active form (5-methyltetrahydrofolate). The downstream result? Impaired methylation, elevated plasm…

…R gene may be part of the reason. MTHFR (Methylenetetrahydrofolate Reductase) is a genetic SNP—a small DNA variation that affects how your body processes folate (vitamin B9). The most common variants, C677T and A1298C, can reduce your abili…

…the root cause: methylation and nutrient deficiencies (B12, folate, B6, and more). High homocysteine isn’t just a number on a test. It’s one of the biggest, most overlooked drivers of PCOS symptoms — and it’s fixable.

…ome don’t matter, but others can throw off key systems like folate metabolism (MTHFR), antioxidant defense (SOD), and glutathione production. While you can’t change your genes, you can support them. At Purser Wellness, we combine genetic an…

… CBS, NAT2, and glutathione-related SNPs that impair copper transport. The solution is supporting ceruloplasmin—the copper-binding protein—with targeted nutrients like B6, zinc, and NAC. That’s why Copper Balance was created: to move copper…

…covorin is simply high-dose folinic acid, a natural form of folate. While it may help some children and has even been promoted as a “cure,” it’s only one piece of the puzzle. True protection comes from supporting the body’s entire defense s…

…bout 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying t…

…n affect how efficiently your body processes nutrients like folate—sometimes cutting function by 40–70%—which is why targeted nutrition and testing matter.

…we see associated with POTS are iron, B6 (pyridoxine), B12, folate, and CoQ10. Deficiencies in any of these can cause dizziness, blood pressure issues, and fatigue. I’ve even solved POTS-like symptoms just by correcting B6 levels! Want to f…