Let’s explore “PAI-1 4G/5G & homocysteine”

PURSER WELLNESSWhat are the ROOT CAUSES of you symptoms?A conversation with Dr. Purser

🧬 After 15+ years deep in genetics, Dr. Purser sees two root causes over and over again: 1️⃣ Inflammation 2️⃣ Gut & liver dysfunction. Almost every chronic issue—including fibromyalgia, fatigue, and brain fog—ties back to 17 homocysteine SNPs or PEMT mutations. That’s why he built treatment guides, books, and the CMA + Redox + genetic testing combo. If you’ve been told “everything looks normal” but still feel awful, this is where to look next. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

If your transsulfuration pathway is off, it’s not just genetics—deficiencies in B6, glutathione, glycine, serine, glutamine, or methionine can block it too. 🧬 Without these, you can’t convert homocysteine to glutathione, leading to inflamma

Ever heard of glutathione? It’s called the “master antioxidant” for a reason—it supports detox, reduces inflammation, and protects every cell in your body from oxidative damage. 🧬 If you have high homocysteine or MTHFR gene variants, chance

Dealing with chronic kidney disease (CRF) or end-stage renal disease (ESRD)? 🩺 The real culprit may not be what you think—high homocysteine levels are a major, often overlooked cause. This triggers the release of harmful cytokines like IL-8

Struggling with inflammation, high cytokines, or conditions like psoriasis, kidney disease, or chronic fatigue? 🧬 The root cause could be elevated interleukins like IL-8 and MCP-1, often triggered by high homocysteine levels. The most power

Struggling with high blood pressure that just won’t budge—even with multiple meds? 😩💊 It might be due to genetic issues causing high homocysteine 🧬, which can stiffen your arteries through IL-8 and MCP-1 cytokines 🧪🫀. I’ve seen patients dr

Glutathione and Cytokines: A Hidden Cause of Renal Disease Did you know the cause of end-stage renal disease, often left untested, is high homocysteine? When homocysteine levels spike, it triggers the release of damaging cytokines like IL-

THE CBS GENETIC SNPS BECOME CRITICAL IF YOU HAVE IT BECAUSE AS THE GATEWAY TO THE TRANSSULFURATION PATHWAY, IF HOMOZYGOUS, IT CAN COMPLETELY SHUT DOWN GLUTATHIONE PRODUCTION ( i.e. actually from conversion of evil, inflammatory homocysteine

1. Fatigue and low energy 2. Mood disorders, such as anxiety or depression 3. Cardiovascular diseases and high homocysteine levels 4. Hormonal issues and fertility problems 5. Difficulty detoxifying 6. Neurological problems, including migra

DirectLabs has a great deal this month for $99 you can get the following levels tested in one panel: Lipids, Fluids & Electrolytes, Liver, Kidney, Glucose, Mineral & Bone, Cardio C-Reactive Protein and HOMOCYSTEINE! It is the CardioPlus Ad

<150 supports deficiency; 150-400 is often treated as borderline and may warrant MMA/homocysteine review.

Follow the sulfur pathway from homocysteine toward cysteine and glutathione.