https://danpursermd.substack.com/p/unlocking-the-mystery-of-intracellular
New Substack article on Biotin Deficiency - symptoms and causes. Like we see time and time again, blood serum levels may show normal amounts, but when you look at in
The Spectracell Intracellular Micronutrient Panel and the Pro7 genetics test we offer are completely different animals. The Spectracell looks at intracellular vitamin, mineral, and amino acid levels and shortages. These shortages are caused
Yes—your genetics can directly cause vitamin deficiencies. Certain SNPs lower your body’s ability to process or make key nutrients, like MTHFR reducing folate use, PEMT lowering phosphatidylcholine production for gut and liver health, and SOD decreasing antioxidant defenses against free radicals. These deficiencies drive inflammation, fatigue, and chronic illness, but with the right genetic and intracellular testing, you can target them and supplement with the exact forms your body needs
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🧪 Blood tests don’t tell the whole story.
Standard serum testing only shows what’s floating in your blood at that moment—not what’s actually inside your cells where nutrients do their work. That’s why I use intracellular testing (CMA)—it r
Genetic mutations like MTHFR, FOLR1, FOLR2, and VDR TAQ don’t just sit there—they cause vitamin deficiencies by blocking absorption or increasing your body’s need for key nutrients. 🧬 That’s why intracellular testing is so critical—it shows
Premature ovarian insufficiency - what is yhe root cause and is it treatable? Yes! Like with most things, let’s get to the intracellular level amd trrat from there.
Get a CMA frol my site and let’s look at over 100 nutrients and what defi
How to reverse osteoporosis? Let’s get the root of several key deficiencies, namely: Calcium, Zinc, D3, K1, and K2.
These are your critical nutrients to observe on the intracellular basis. If you’re deficient in these, your bones will beg
Do you want to know how GREAT your cells are? Do you want to make your health AMAZING again by fixing any BAD nutrients? If so, you need intracellular micronutrient testing.
Cellular micronutrient testing is an amazing blood panel that mea
Can the B vitamins you are taking to support energy and methylation eventually make you feel worse?
In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as:
• 5-MTHF or methylfolate
• Methylcobalamin
• Trimethylglycine, also called TMG
• Multiple overlapping methylation formulas
Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.”
These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered.
In this video, we discuss:
• Why methylation is essential
• How methyl-donor supplements support the body
• Why the right vitamin can become the wrong dose
• Ingredients to look for on your supplement labels
• Why some people may need lower doses or non-methylated forms
• How genetics and intracellular nutrient testing can guide a more personalized plan
At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual.
Learn more or schedule with Purser Wellness:
https://danpursermd.com
Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional.
#Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness
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MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets
If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.”
In this video, we break down exactly why this happens:
How MTHFR/methylation issues impair ATP (energy) production at the cellular level
Why your body desperately reaches for quick glucose
The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage
The downstream effects on antioxidants, DNA repair, and overall energy
How to finally break the cycle:
Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests)
Why our MTHFR Daily multivitamin was specifically formulated for this
The power of CMA intracellular testing
Intermittent fasting (12–16 hrs)
Fasted cardio (even just a brisk walk)
High-protein, real-food diet with minimal processed sugars
If you’re tired of the sugar rollercoaster and want stable energy, this is for you.
Links:
Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle
Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com
Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily
Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious!
#MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting
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In this consultation review, Jackson sat down with longtime Purser Wellness patient Lois Schweigert to go over her latest intracellular micronutrient (CMA) test results.
After years of dealing with fibromyalgia, pain, gut issues, and inconsistent energy, Lois has made remarkable progress. Her newest CMA shows ZERO deficiencies — her best results ever — and it perfectly matches how great she’s been feeling.
We discuss:
• Her consistent weight training and dramatically improved recovery (thanks to catalase!)
• Key optimization tweaks: amino acids, omega-3s, chromium, inositol, and glutathione
• Blood sugar stability
• Sleep support and overnight recovery
• How trauma & stress affect your nutrient levels
• Why intracellular testing is so unique and powerful
If you’re dealing with chronic symptoms, poor workout recovery, or just want to optimize your health, this conversation is packed with practical insights from real patient results.
👉 Ready to get your own CMA? Visit danpursermd.com or comment “CMA” below and we’ll send you info.
#PurserWellness #Fibromyalgia #RootCauseHealth #CMATest #FunctionalMedicine
This video is for educational purposes only and is based on Dr. Dan Purser’s protocols. Not medical advice. Always consult with your healthcare provider.
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🔬 What is VARS? Why the VARS Trio (Glutathione + SOD + Catalase) is a game-changer for inflammation, recovery & fibromyalgia.
Jackson Larkin sits down with Lois Schweiger to break down Dr. Dan Purser MD’s VARS line — Validated, Absorbable, Reduced, and Stable antioxidants. Learn the science behind VARS Glutathione, VARS SOD (from deep-sea algae near volcanic vents), and the newest VARS Catalase (Nrf2 activator from seaweed).
Discover:
• How the VARS Triad works together in the mitochondria to fight oxidative stress and cytokines
• Why Catalase dramatically improved post-workout recovery (especially leg day!)
• Genetics, homocysteine, PEMT, and why many with fibro benefit from this protocol
• The importance of CMA (intracellular) testing and when to retest
• Real patient results, including severe inflammation cases
Perfect for anyone dealing with chronic pain, inflammation, slow recovery, or looking for root-cause support.
**June Anniversary Special**: $100 off Genetic + CMA testing — one order will be fully reimbursed!
👉 Learn more & shop VARS supplements: danpursermd.com
#VARSGlutathione #Fibromyalgia #Antioxidants #ChronicInflammation #PurserWellness #Catalase #SOD
Timestamps:
00:00 Intro & What Does VARS Mean?
01:45 The Science of the VARS Triad
12:00 Who Needs the Trio?
14:00 Catalase & Workout Recovery Stories
20:00 Genetics, Homocysteine & Testing
Follow Dr. Purser!
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
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