Let’s explore “Cytokines, including IL-6 and TNF-α — lab reference”

This TNF promoter variant appears in Dr. Purser’s discussion of inflammatory signaling.

Explore macrophage inflammatory protein-1 alpha, CCR1, CCR5, and the recruitment of myeloid cells and lymphocytes.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, genetics and methylation.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, genetics and methylation.

PURSER WELLNESSDefeat Inflammation with Super Antioxidants?A conversation with Dr. Purser

Superoxide Dismutase 3 (SOD 3), also known as extracellular SOD or ubiquitous SOD, plays a critical role in your body’s defense against inflammation and oxidative stress. Here’s why it matters: Stabilizes Mast Cells SOD 3 helps suppress mast cell activation, reducing the release of inflammatory mediators that contribute to conditions like skin inflammation, inflammatory bowel disease, and chronic pain. Reduces Pro-Inflammatory Cytokines By inhibiting cytokines like TNF-Alpha, SOD 3 can help soothe inflammation at its source. Supports Healthy Joints and Blood Vessels Whether you have joint disc

… discomfort. Follow the pathway Dr. Purser discusses IL-6, TNF-alpha, other inflammatory signals, tissue remodeling, and the interaction between inflammation and hormone-related processes. Cytokines are one part of the picture, rather than…

…ti-inflammatory brake. This provides a useful contrast with TNF, IL-1β and IL-6 in the teaching encyclopedia. Neither a single common variant nor one blood measurement establishes that the entire anti-inflammatory system has failed. A quest…

…es hepatic stellate cells, fibrosis, and the interaction of cytokines with reactive oxygen species. He follows the antioxidant partnership of glutathione, superoxide dismutase, and catalase while also considering nutrition and the metabolic…

…ause of migraine. Follow the pathway His teaching connects cytokines, homocysteine, oxidative stress, and the trigeminal pain pathway. Conventional migraine discussions include triptans and CGRP-directed therapies; nutrient and antioxidant…

PURSER WELLNESSFrom Bedridden to Thriving: Our Real Fibromyalgia JourneyA conversation with Dr. Purser

🎉 June Anniversary Special at Purser Wellness! Join Dr. Dan Purser MD’s team — Chantel (Chicky), Denise Purser, and Lois Schweigert from End Fibro with Natural Options — for an honest, heartfelt conversation about living well with fibromyalgia. We share real-life stories of flares, recovery, and ongoing improvement using Dr. Purser’s protocol. From severe teenage fibromyalgia to thriving as grandmothers, we discuss how the VARS Trio (Glutathione, SOD, and the game-changing Catalase) helps manage inflammation, cytokines, and hydrogen peroxide — plus practical tips on low-copper diet, serving sizes, gym recovery, weight loss, and consistency over perfection. Topics covered: • How to handle fibro flares quickly (catalase + SOD stories) • The importance of intracellular testing (CMA) & genetics • Low-copper eating guidelines & why serving size matters • Building strength and muscle after years of pain • Why we keep improving year after year 🔥 June Special: $100 off Genetic Testing + CMA (deepest discount of the year). One lucky order will be fully reimbursed! 👉 Order tests & supplements: https://danpursermd.com (or link in comments) If you or someone you love deals with fibromyalgia, chronic pain, fatigue, or inflammation, this episode is full of hope and actionable advice. 💬 Drop your biggest takeaway or question below — we read every comment! Timestamps: 00:00 - Intro & June Anniversary Sale 02:30 - Real flare story & catalase rescue 06:00 - Long-term improvement on the protocol 12:00 - Starting slow with supplements (topical tips) 23:00 - Low-copper diet & food list tips 36:00 - Gym recovery & building muscle 50:00 - Weight loss benefits & consistency #Fibromyalgia #ChronicPain #NaturalWellness #PurserWellness #FibroRecovery #LowCopperDiet Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss From the reading room

…homocysteine, and a body-wide amplification of inflammatory cytokines. Homocysteine is not merely a cardiovascular marker. It is a potent “cytokine amplifier.” When levels climb above 10–12 µmol/L (my functional optimum is <7–8 µmol/L), hom…

🚨 High homocysteine isn’t just a lab number—it’s a warning sign. Genes like MTHFR, MTR, MTRR, and GGH can overactivate the methylation cycle and lead to hyperhomocysteinemia, which drives inflammation, stroke risk, and even kidney failure…