Can the B vitamins you are taking to support energy and methylation eventually make you feel worse?
In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as:
• 5-MTHF or methylfolate
• Methylcobalamin
• Trimethylglycine, also called TMG
• Multiple overlapping methylation formulas
Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.”
These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered.
In this video, we discuss:
• Why methylation is essential
• How methyl-donor supplements support the body
• Why the right vitamin can become the wrong dose
• Ingredients to look for on your supplement labels
• Why some people may need lower doses or non-methylated forms
• How genetics and intracellular nutrient testing can guide a more personalized plan
At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual.
Learn more or schedule with Purser Wellness:
https://danpursermd.com
Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional.
#Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness
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What if your food isn't as nutritious as you think?
Calories are easy to count.
Protein is easy to track.
But the real story lies in the vitamins, minerals, antioxidants, and trace nutrients your body depends on every single day.
Most
MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets
If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.”
In this video, we break down exactly why this happens:
How MTHFR/methylation issues impair ATP (energy) production at the cellular level
Why your body desperately reaches for quick glucose
The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage
The downstream effects on antioxidants, DNA repair, and overall energy
How to finally break the cycle:
Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests)
Why our MTHFR Daily multivitamin was specifically formulated for this
The power of CMA intracellular testing
Intermittent fasting (12–16 hrs)
Fasted cardio (even just a brisk walk)
High-protein, real-food diet with minimal processed sugars
If you’re tired of the sugar rollercoaster and want stable energy, this is for you.
Links:
Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle
Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com
Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily
Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious!
#MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting
Follow Dr. Purser!
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
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What if the answers you've been searching for aren't found in another prescription—but inside your own cells?
Most lab tests tell you what's circulating in your blood. But what if your cells are telling a different story?
A Cellular Micro
What if everything you’ve been told about PCOS is missing the real culprit?
Homocysteine isn’t just a random lab marker—it may be the hidden thread tying together hormone imbalance, inflammation, and the symptoms so many are struggling to m
Dr. Purser dives into the root causes of low testosterone in men. As always, "Good nutrition in, means good hormones out." Could low testosterone levels be linked to severe vitamin deficiencies caused by genetic errors such as MTHFR? Dr. Purser has found this to be the case for many of his patients. Find out how you can start feeling great today! Testing discussed: SpectraCell Intracellular Micronutrient Panel, Pro7 Genetic Testing, and Direct Labs Free and Total Testosterone Levels. See all testing options at https://DanPurserMD.com/genetics-testing. Contact us at (801) 796-7667 or info@danpu
Do you suffer from Chronic Renal Failure? Learn why you need to stop using NSAIDs and monitor your protein intake. Explore natural options to supplement therapies your primary care physician has prescribed. Discover how a validated and absorbable glutathione can be beneficial in restoring low glutathione levels found in chronic renal patients. Contact us at (801) 796-7667 or info@danpursermd.com for help. Check back often for the newest updates!
Thyroid health remains essential during menopause. Optimal labs should show FT3 around 4.0 and FT4 near 1.5, and testing through Direct Labs makes it easy to track. Supporting with supplements like Thyromin can help, but only if guided by accurate lab results.
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
Facebook: https://www.facebook.com/danpursermd
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Copper is essential for life—it helps enzymes work, supports SOD1 for antioxidant defense, and even prepares iron to carry oxygen in the blood. But when copper builds up in the bloodstream instead of entering cells, it causes pain, tender points, and migraines. This often ties back to genes like CBS, NAT2, and glutathione-related SNPs that impair copper transport. The solution is supporting ceruloplasmin—the copper-binding protein—with targeted nutrients like B6, zinc, and NAC. That’s why Copper Balance was created: to move copper where it belongs and help symptoms finally improve. Visit PhysicianDesigned.com or Amazon for Copper Balance.
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
Facebook: https://www.facebook.com/danpursermd
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PQQ is a powerful nutrient that doesn’t just boost energy—it actually creates new mitochondria, helping cells regenerate and fight aging. It also helps break down beta amyloid plaque, the sticky protein linked to dementia and Alzheimer’s. T
PQQ is a powerful nutrient that doesn’t just boost energy—it actually creates new mitochondria, helping cells regenerate and fight aging. It also helps break down beta amyloid plaque, the sticky protein linked to dementia and Alzheimer’s. T
🧩 Ever wonder how Copper Balance actually works?
It supports ceruloplasmin, the protein that moves copper safely in and out of your cells. ⚙️ With a patented blend of zinc, molybdenum, boron, NAC, and other nutrients, Copper Balance helps
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