Let’s explore “B12”

Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine.

Helps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.

TCN2 helps carry vitamin B12 in the body. A gene result alone cannot tell you your B12 status.

Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.

Encodes cubilin, part of a receptor system involved in uptake of the intrinsic-factor–B12 complex.

PURSER WELLNESSOVER-METHYLATION - Are Your B Vitamins Hurting You?A conversation with Dr. Purser

Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

PURSER WELLNESSWhat is MTHFR? What can YOU do about it?A conversation with Dr. Purser

MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.

PURSER WELLNESSHomocysteine is the Secret AssasinA conversation with Dr. Purser

Homocysteine is nasty — but here’s the truth no one tells you. It doesn’t kill you directly — it triggers white blood cells to release IL-8 and MCP-1, causing inflammation, kidney failure, heart attacks, and strokes. Most doctors don’t even check it anymore, thinking there’s no fix. But there is. Whether from 17 genetic SNPs or 12 vitamin deficiencies (like B6 or B12), you can address it by supporting your body’s ability to convert homocysteine into glutathione.

PURSER WELLNESSPossible Cause of Crohn's Disease?A conversation with Dr. Purser

Dr. Purser talks about a meta-analysis where correlations are drawn between Crohn's disease, ulcerative colitis, inflammatory bowel diseases, and B12 folate deficiencies. However, it is unclear how each are directly related. PubMed Study: https://pubmed.ncbi.nlm.nih.gov/28406440/ Contact us at (801) 796-7667 or info@danpursermd.com for help. Subscribe to stay up-to-date with new content!

PURSER WELLNESSNeuropathy Caused by Vitamin Deficiency?A conversation with Dr. Purser

Explore the relationship of vitamin deficiency and neuropathy, a painful and disabling condition. Learn how a SpectraCell Comprehensive Nutritional Panel can help reveal intracellular deficiencies. Explore the relationship of how genetic diseases, such as MTHFR, relate to neuropathy. Discover how Methyl B12 (Methylcobalamin) may treat neuropathy. Contact us at (801) 796-7667 or info@danpursermd.com for help. Check back often for the newest updates!

Insulin resistance starts long before high blood sugar shows up — and it often begins with deficiencies in zinc, B12, chromium, selenium, and omega-3s. Fix the deficiencies, and you can often restore

PURSER WELLNESSWhich Vitamins Prevent Iron Deficiency?A conversation with Dr. Purser

If you are low or think you're low in Iron, you HAVE to try Vitamin B12 and Vitamin C to boost your levels. Seeking Health has a great Methyl Free B vitamin complex, and our VARS Vitamin C from PhysicianDesigned.com is your best option for FUNCTIONAL vitamin C. Boost your levels and always remember you can get a CMA Intracellular Test if you want to see your other levels. Reach to my office with any questions. 801-796-7667 Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd