…egion also contains regulatory elements relevant to the nearby IL4, IL5 and IL13 cluster, so a locus association can concern more than the coding function of one gene.
Also called:
DNA repair and a nearby Th2 regulatory region
RAD50 encode…
TGFB1 encodes transforming growth factor beta 1, which has roles in immune regulation, tissue repair and extracellular-matrix production. Its effects can include both regulation of inflammation and promotion of fibrosis.
Also called:
Repai…
…e in regulated cell-death pathways. TRAIL itself is encoded by TNFSF10.
Also called:
DR4 receives the TRAIL signal
TNFRSF10A encodes death receptor 4, or DR4, a receptor that can receive the TRAIL signal and participate in regulated cell-d…
…ll death through particular receptors. It is a different member of the TNF-related signaling family from TNF itself.
Also called:
TRAIL and regulated cell death
TNFSF10 encodes TRAIL, a signaling protein involved in regulated cell death th…
…en simple steps, explore the side routes, and tap a word or building block to learn more.
Also called: Transsulfuration, Transsulphuration, Sulfur pathway, Cysteine synthesis, Glutathione synthesis, CBS pathway, CTH pathway
Two directions f…
… recruit monocytes through the CCR2 receptor. Monocytes can become macrophages, cells that remove debris and participate in inflammation.
Follow the pathway
Dr. Purser follows the CCL2–CCR2 pathway through blood-vessel, kidney, and metabol…
Explore membrane and soluble CD14, lipopolysaccharide (LPS), TLR4, and innate immune activation.
Understand the connection
CD14 helps the immune system recognize lipopolysaccharide, or LPS, from the outer surface of certain bacteria. It ap…
Explore CD40L, antigen-presenting cells, antibody class switching, and autoimmunity.
Understand the connection
CD40 is a receptor involved in communication between immune cells. Its partner, CD40L, helps activated T cells communicate with …
…AP is an accessory part of the IL-18 receptor. IL18R1 helps bind the cytokine; IL18RAP helps the receptor complex send its signal inside the cell.
Follow the pathway
Dr. Purser follows this receptor complex through MyD88 and NF-κB signalin…
…h17 cells, IL-21R, JAK/STAT terminology, and cellular redox balance.
Understand the connection
IL-21 is produced by immune cells including follicular helper T cells and Th17 cells. It influences B cells, antibody responses, and other parts…
Explore Toll-like receptor 2, microbial and damage signals, TLR1, TLR6, and MyD88 signaling.
Understand the connection
TLR2 is a pattern-recognition receptor that helps immune cells detect components of microbes and damaged tissue. It ofte…
…en kidney function declines, homocysteine levels often rise because the kidneys play an important role in its metabolism and clearance. In people with chronic kidney disease, elevated homocysteine is common and has been studied in connectio…
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