Let’s explore “Polymyalgia rheumatica and inflammation”

An amino acid used in protein synthesis and other metabolic processes.

A family of enzymes made by the body that convert superoxide into hydrogen peroxide.

Needed for nerve function, DNA production and healthy red blood cells.

Forms enzyme helpers used in energy metabolism.

Supports DNA synthesis and one-carbon metabolism, including the pathway that processes homocysteine.

The genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH).

Encodes diamine oxidase, an enzyme involved in breaking down histamine and other amines. DAO is used here as an enzyme nickname; it is also the official symbol of a different gene.

BHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway.

CBS helps move homocysteine into the pathway that supplies building blocks for glutathione.

CD14 helps immune cells recognize microbial components, including bacterial lipopolysaccharide, as part of innate immune signaling. This places it upstream of some cytokine responses.

CHDH helps convert choline toward betaine, a nutrient involved in the homocysteine pathway.

COL5A1 encodes one component of type V collagen, which helps organize collagen fibers. It connects to the strength and structure of tendons, skin and other connective tissues.