THE PURSER WELLNESS ENCYCLOPEDIA

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Gene referenceSep 23, 2026

APOE

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APOE encodes a protein that carries lipids between cells. The familiar APOE e2, e3 and e4 groupings depend on the combination of rs429358 and rs7412, not on either marker read in isolation. Also called: Apolipoprotein E Lipid transport and …

Gene referenceSep 23, 2026

BHMT

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…recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway. Also called: BHMT08, Betaine-Homocysteine S-Methyltransferase Another route through the homocysteine map BHMT is part of the pathwa…

Gene referenceSep 23, 2026

BRCA2

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BRCA2 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding. Also called: Breast Cancer 2 DNA repair and inherited ca…

Gene referenceSep 23, 2026

CBS

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… helps move homocysteine into the pathway that supplies building blocks for glutathione. Also called: Cystathionine Beta-Synthase From homocysteine toward glutathione Dr. Purser places CBS in the sulfur-handling pathway that connects homocy…

Gene referenceSep 23, 2026

CD14

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CD14 helps immune cells recognize microbial components, including bacterial lipopolysaccharide, as part of innate immune signaling. This places it upstream of some cytokine responses. Also called: Cluster of Differentiation 14 How immune ce…

Gene referenceSep 23, 2026

CHDH

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CHDH helps convert choline toward betaine, a nutrient involved in the homocysteine pathway. Also called: Choline Dehydrogenase Choline can serve more than one purpose CHDH helps convert choline toward betaine, while PEMT helps make phosphat…

Gene referenceSep 23, 2026

COMT

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Makes an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance. Also called: Catechol-O-Methyltransferase Catecholamines and sensit…

Gene referenceSep 23, 2026

CTH

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CTH helps make cysteine, one of the building blocks your body uses to make glutathione. Also called: Cystathionine Gamma-Lyase From homocysteine toward glutathione Dr. Purser places CTH in the sulfur-handling pathway that connects homocyste…

Gene referenceSep 23, 2026

DHFR

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DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells. Also called: Dihydrofolate Reductase R…

Gene referenceSep 23, 2026

FADS2

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Encodes an enzyme involved in fatty-acid metabolism. Also called: Fatty Acid Desaturase 2 / D6D The form of a fatty acid matters Dr. Purser teaches FADS genes as a conversion pathway. FADS2 participates in a delta-6 desaturase step in fatty…

Gene referenceSep 23, 2026

FOLR2

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FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier. Also called: Folate Receptor …

Gene referenceSep 23, 2026

FTO

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FTO is studied in relation to body weight and energy balance. Common variants can contribute to population-level differences in obesity susceptibility, alongside many other genes and environmental factors. Also called: Fat Mass and Obesity-…

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