Let’s explore “IL23R”

🧬 MTHFR Mutations, High Homocysteine & Autoimmune Disease: The Hidden Root Cause Most Doctors Miss For decades, patients with RA, lupus, MS, Hashimoto’s, and fibromyalgia chase symptom relief with meds that never fix the underlying fire. A

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss From the reading room

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

PURSER WELLNESSCan Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High HA conversation with Dr. Purser

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step https://danpursermd.substack.com/p/can-glutathione-reverse-kidney-disease?utm_source=youtube

A sudden spike in folate or homocysteine is rarely caused by supplements. It is most often the result of a hidden infection or minor injury triggering a cytokine surge. Identifying and treating the underlying source is the key to bringing l

Years ago, I watched cystic fibrosis (CF) patients receive nebulized glutathione that didn’t seem to help. Decades later, our team developed and patented the first fully functional, reduced, and stable form — VARS Glutathione. Why does thi

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, pain and wellbeing.

Homocysteine is a natural molecule your body makes, but when levels get too high it drives massive inflammation by triggering cytokine release. For some people, genetics or deficiencies cause a “fixed homocysteine rate,” meaning diet and vi

PURSER WELLNESSWhat Is A Fixed Homocysteine Rate?A conversation with Dr. Purser

Homocysteine is a natural molecule your body makes, but when levels get too high it drives massive inflammation by triggering cytokine release. For some people, genetics or deficiencies cause a “fixed homocysteine rate,” meaning diet and vitamins alone won’t lower it. In those cases, the only real way to balance it is by supporting the pathway that converts homocysteine into glutathione. That’s why reduced, stable glutathione—like VARS Glutathione—is essential, because most products are oxidized and useless by the time you take them. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Your body’s ability to detox depends on one critical pathway—turning homocysteine into glutathione. But for millions with MTHFR or other genetic SNPs, this process is broken, leaving them vulnerable to toxins, inflammation, and cytokine sto