THE PURSER WELLNESS ENCYCLOPEDIA

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A RELATED COURSEYour MTHFR starting point

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Gene referenceSep 23, 2026

GGH

GGH encodes gamma-glutamyl hydrolase, which removes glutamate residues from folate compounds. This affects folate handling and helps explain why folate metabolism includes retention and processing as well as intake.

Gene referenceSep 23, 2026

GSR

GSR encodes glutathione reductase. It uses reducing power from NADPH to help convert oxidized glutathione back to reduced glutathione, allowing this antioxidant system to be reused.

Gene referenceSep 23, 2026

HFE

HFE helps regulate iron absorption through signaling that influences hepcidin. The commonly discussed C282Y and H63D variants correspond to rs1800562 and rs1799945. Their implications depend on the combination present and clinical findings.

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