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FROM THE PURSER BOOKSHELF · CHAPTER GUIDE

Homocysteine, D-dimer and inflammatory markers

See what homocysteine, D-dimer, and CRP each measure.

Based on teaching by Dan Purser, MD. How we prepare these guides

Educational summary

Why this matters

See what homocysteine, D-dimer, and CRP each measure.

How the pieces connect

D-dimer relates to clot breakdown; CRP relates to inflammation; homocysteine is a different molecule. Ask what each test was ordered to investigate.

Different markers answer different questions

Dr. Purser puts several measurements next to one another, but a shared discussion does not make them interchangeable. D-dimer relates to breakdown of cross-linked fibrin; CRP is an inflammatory marker, and hsCRP is a more sensitive way of measuring low CRP concentrations. Homocysteine is a different molecule again. Dr. Purser proposes biological connections among them. Reading them as a panel of clues is more useful than treating any one as a complete explanation for the others.

Keep in mind

These tests measure different things. An elevated D-dimer or symptoms of a possible clot need prompt medical assessment, regardless of a proposed homocysteine connection.

A question for your next conversation

What question was each test ordered to answer?

BUILD YOUR UNDERSTANDING

A few concepts, made clearer.

MTHFR

Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.

Read the full reference

LET YOUR CURIOSITY LEAD

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