Genes in the homocysteine conversation | Purser Wellness Encyclopedia

Why this matters

Learn how to read a specific genetic variant before drawing conclusions about homocysteine.

How the pieces connect

Folate, B12, and sulfur pathways involve many genes. The exact variant and its classification tell you more than a gene name or a colored app result.

Read the variant, not just the gene name

A gene is a set of instructions; a variant is a particular difference in those instructions. Different variants in the same gene can have very different significance. “Homozygous” describes having the same variant in both copies at a location; it is not a severity score. MTHFR C677T and A1298C therefore need to be read as specific findings in context, not as proof that all of methylation is blocked. Dr. Purser’s gene list is a map of topics to investigate.

The wider genetic map in the final book

Chapters 3–4 and 11 of Outlive Your Toxic Genetics expand the discussion from MTHFR to folate handling, B12 transport/use, SAM/SAH regulation and transsulfuration. Examples include AHCY, BHMT, FOLH1, MTR/MTRR, SHMT1, TCN2, MTHFD1/MTHFD1L, SLC19A1, CBS and CTH. These names help organize a lesson; the exact variant and clinical classification still matter. Dr. Purser’s “22 SNPs” terminology is a teaching framework, not a substitute for verifying a laboratory result or a treatment rule.

Keep in mind

A gene list cannot diagnose you. A common variant, even in both copies, does not by itself prove high homocysteine, an immune problem, or a need for supplements.