Let’s explore “Environmental exposure, inflammation, and transsulfuration questions”

Chronic inflammatory response syndrome, or CIRS, is a term used in some clinical discussions of persistent symptoms after environmental exposures.

Separate questions about toxin exposure from questions about genetics and antioxidant pathways.

See how homocysteine connects to cysteine and glutathione. Follow seven simple steps, explore the side routes, and tap a word or building block to learn more.

Explore the history, production signals, nutrient context and monitoring that shape Dr. Purser’s hormone assessment.

A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.

PURSER WELLNESSAutism Answered - Root Cause Solved with #1 Reviewed MD in the USAA conversation with Dr. Purser

Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.

PURSER WELLNESSToxins Are Especially Bad For YOU!A conversation with Dr. Purser

Why do some people in the same family get destroyed by black mold… while others are completely fine? Why do two kids develop autism while their siblings are completely normal? Dr. Dan Purser explains the hidden genetic issue behind both: a homocysteine problem that disrupts the transsulfuration pathway — the pathway responsible for making ~90% of your glutathione. Without enough glutathione, your body simply cannot clear toxins. Mold, heavy metals, environmental chemicals… they stay stuck. This is why some people get chronically ill and others don’t, even when living in the exact same house. In this episode we cover: How a genetic disruption in the transsulfuration pathway causes low glutathione Why most “glutathione” products on Amazon do nothing The only two patented forms that actually work Real cases of black mold toxicity and autism improvement Why checking genetics is more important than just checking a homocysteine level This is root-cause medicine — not symptom chasing. Learn more: Website: https://danpursermd.com Two Glutathione: https://twoglutathione.com Substack: https://danpursermd.substack.com Office: (801) 796-7667 Email: info@danpursermd.com #Homocysteine #Glutathione #BlackMold #Autism #Detox #RootCauseMedicine #PurserWellness #Genetics

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

…, yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taugh…

Chapter 10: The Impact of Homozygous Genetic SNPs on the Transsulfuration Pathway and Their Role in Toxicology and Inflammation Genetics and the transsulfuration pathway Why this matters Follow the sulfur pathway from homocysteine toward …

The folate cycle, methionine cycle, and transsulfuration pathway work together to move methyl groups and process homocysteine.

What if mold exposure is only part of the story? Two people can share the same environment and have completely different experiences. Why? The answer may involve far more than the mold itself. Glutathione is one of the body's major anti…

A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.