Let’s explore “hyperhomocysteinemia”

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, pain and wellbeing.

Explore SERPINE1 / PAI-1, rs1799889, 4G/5G, fibrinolysis, hyperhomocysteinemia (HHcy), vascular health, and differences between approaches to clotting risk.

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

PURSER WELLNESSCan Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High HA conversation with Dr. Purser

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step https://danpursermd.substack.com/p/can-glutathione-reverse-kidney-disease?utm_source=youtube

🚨 High homocysteine isn’t just a lab number—it’s a warning sign. Genes like MTHFR, MTR, MTRR, and GGH can overactivate the methylation cycle and lead to hyperhomocysteinemia, which drives inflammation, stroke risk, and even kidney failure.

PURSER WELLNESSThe Master MTHFR Protocol Dr. Purser DesignedFrom the reading room

…aged. Downstream Effects: Unmanaged variants lead to severe hyperhomocysteinemia, a major driver of heart attacks, strokes, hypertension, and kidney failure. If you want the deep dive on this science, read my textbook, HOMOCYSTEINE. Oddly e…

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss From the reading room

…gression, and elevated Th17 cytokines (IL-17, IL-6, TNF-α). Hyperhomocysteinemia is documented in ankylosing spondylitis, juvenile idiopathic arthritis, and Hashimoto’s, with homocysteine levels directly tracking disease activity. I have se…

…he precursor to), which can cause high homocysteine levels (hyperhomocysteinemia), which causes vascular inflammation which in turn can increase your risk of coronary heart disease (arteriosclerotic vascular disease or venous thrombosis), a…

…he precursor to), which can cause high homocysteine levels (hyperhomocysteinemia), which causes vascular inflammation which in turn can increase your risk of coronary heart disease (arteriosclerotic vascular disease or venous thrombosis), a…

…CARRIAGES 12. POST PARTUM DEPRESSION 13. YOUNG CAD STROKES (HYPERHOMOCYSTEINEMIA) 14. HYPOTESTOSTERONISM or HYPOGONADISM 15. PREMATURE MENOPAUSE 16. OVARIAN INSUFFICIENCY 17. And more . LABS: OUR FOUNDATION METHYLATION GENETICS TEST (10 da…

… that cause severe MTHFR deficiency. Topics: homocysteine, hyperhomocysteinemia, remethylation, transsulfuration, methionine, folate, B12, B6, kidney function

Chapter 3: Twenty-Two Genetic SNPs Associated With Hyperhomocysteinemia Genes in the homocysteine conversation Why this matters Learn how to read a specific genetic variant before drawing conclusions about homocysteine. How the pieces co…