Let’s explore “MTHFR, homocysteine, and immune signals”

Explore transsulfuration, methylation, glutathione, genetic variants, cytokines, and possible connections.

PURSER WELLNESSMTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving SweetsA conversation with Dr. Purser

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Dan Purser MD and Jackson Larkin discuss the connections they consider between sugar cravings, cellular energy, and methylation.

PURSER WELLNESSMTHFR and The 85% SolutionA conversation with Dr. Purser

Do you have problems with depression but most antidepressants made it worse? Are you fatigued all the time despite stimulants and amphetamines doctors readily prescribe? Do regular vitamins give you a stomach aches and nausea? The newest book from best-selling (ten #1 books on Amazon) author Dan Purser MD addresses these issues. Learn how most of the United States population carries the gene for this mysterious disorder, MTHFR. An increasing number of people realize they suffer from symptoms of MTHFR (methylation problems, folate deficiencies, and lack of methylfolate). Learn how it's killing

PURSER WELLNESSWhat is MTHFR?A conversation with Dr. Purser

Dr. Purser explains the diagnosis and treatment of MTHFR (methylenteterahydrofolate reductase enzyme deficiency disease). Learn the genetic component of this illness (such as C677T or A1298C) and how it affects the body's inability of methylation to convert carbohydrates into ATP (Adenosine Triphosphate). Discover how the complex enzyme pathways of the Krebs cycle and citric acid cycle convert carbohydrate molecules into ATP molecules in the mitochondria. Explore the relationship of MTHFR to vitamin and hormone deficiencies while understanding how vitamin supplements can replace key missing (u

A sudden spike in folate or homocysteine is rarely caused by supplements. It is most often the result of a hidden infection or minor injury triggering a cytokine surge. Identifying and treating the underlying source is the key to bringing l

Every woman with PCOS I’ve ever tested has a homocysteine problem... That’s what Dr. Dan Purser says — and it might explain why so many women with PCOS struggle with pain, inflammation, fatigue, and even kidney or blood pressure issues. Hom

The NEW & improved MTHFR Endure is here! 🚨 Elevate your energy, boost your mood, and support vibrant, everyday wellness. This next-gen formula is designed to power your body’s natural methylation pathways—key for detox, brain function, and

A post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.

A post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.

Doctors have spent decades trying to lower homocysteine with B6, B12, folate, or $12,000/month injections. But it’s not the homocysteine doing the damage—it’s the IL-8 and MCP-1 cytokines it releases. That’s where glutathione (especially VA

PURSER WELLNESSTreating Homocysteine May Treat The WORLD!A conversation with Dr. Purser

Doctors have spent decades trying to lower homocysteine with B6, B12, folate, or $12,000/month injections. But it’s not the homocysteine doing the damage—it’s the IL-8 and MCP-1 cytokines it releases. That’s where glutathione (especially VARS or Glutaryl) changes the game. We’ve seen cytokine levels drop to zero—and symptoms vanish. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd