THE PURSER WELLNESS ENCYCLOPEDIA
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What’s searchable?VKORC1 encodes vitamin K epoxide reductase, part of the vitamin K recycling system used in activating clotting proteins. It is not simply a vitamin K receptor. Also called: Vitamin K Epoxide Reductase Complex Subunit 1 Recycling vitamin K a…
How the Purser approach moves from a nutrient finding to priorities, a manageable plan and reassessment. Also called: From a laboratory flag to a useful plan Start with your original CMA report: check its date, values, and the lab’s catego…
Understand why Dr. Purser teaches glutathione, SOD and catalase as a connected antioxidant team. Also called: An antioxidant team with different jobs Dr. Purser teaches redox defense as a connected team. SOD handles superoxide and produces…
Separate the gene, variant, measured value and clinical interpretation—and learn which questions to bring to your visit. Also called: Keep the original result in view Start with your original report: check the date, units, the lab’s range,…
Encodes the reduced folate carrier, a protein involved in transporting folates into cells. Also called: RFC1, reduced folate carrier, folate transport Folate transport is part of the story Dr. Purser’s folate map includes transport as well …
ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme important to bone and tooth mineralization and vitamin B6 metabolism. Persistently low alkaline phosphatase can deserve a different evaluation from a general nutrient deficienc…
DDAH1 encodes an enzyme that breaks down asymmetric dimethylarginine, or ADMA. ADMA inhibits nitric oxide synthase; DDAH1 is part of its clearance system, not the inhibitor itself. Also called: Clearing ADMA helps preserve nitric oxide sig…
F9 encodes coagulation factor IX. Disease-causing variants can result in hemophilia B, an inherited bleeding disorder, but a panel marker is not equivalent to a confirmed disease-causing finding. Also called: Factor IX and the bleeding sid…
IL18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coordinated components to translate an extracellular signal into a cellular response. Also called: The accessory component of IL-18 signaling IL18RAP en…
IL1B encodes interleukin-1 beta, a cytokine involved in inflammatory responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of having a common SNP. Also called: IL-1β and the early infl…
IL23A encodes the p19 subunit of interleukin-23. Together with the p40 subunit encoded by IL12B, it forms a cytokine involved in supporting Th17 responses. Also called: The p19 component of IL-23 IL23A encodes the p19 subunit of interleuki…
MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate. Also called: Folinic acid has …
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