THE PURSER WELLNESS ENCYCLOPEDIA

Let’s explore “MTHFR”

Explore this topic as a step-by-step interactive map.MTHFR, the citric acid cycle & ATP
A RELATED COURSEYour MTHFR starting point

5 chapters, at your pace

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New to this subject? Start with this free introduction.Crash Course on MTHFR & Genetic Terminology

656 resources for your curiosity110 matching listings grouped; alternative sources stay available.

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YouTubeJun 5, 2026

Where To Find Dr. Purser Online (Deplatformed)

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Dr. Dan Purser here with an important update from Purser Wellness. Earlier this week we were deplatformed on a major platform right after discussing groundbreaking findings from our homocysteine research — particularly its connections to ASD, ADHD, cytokine issues, and inflammatory conditions like polymyalgia rheumatica (PMR). Despite losing access to our old page (and nearly 200,000 followers), we’re back stronger with a brand new official page! ✅ Follow our new official Facebook page here: https://www.facebook.com/purserwellness We’re keeping things focused and continuing our important work on root-cause wellness, intracellular nutrient deficiencies, genetics, glutathione/SOD balance, and more. ### Where to Stay Connected: - Substack (Daily research articles & in-depth content): https://substack.com/PurserWellness or https://danpursermd.substack.com - YouTube – Live streams and full recordings will continue here (plus TikTok, Instagram, and podcast platforms) Dr. Purser’s message is clear: We will not stop the research. “I’ll quit when I die… and maybe not even then.” If you’ve been following our work on homocysteine, MTHFR, cytokine problems, hormone optimization, and functional medicine protocols, please: - Like and follow the new Facebook page - Subscribe to Substack - Share this video with friends and patients who need this information Thank you for your incredible support during this transition. Your follows and shares help us keep delivering the cutting-edge research no one else is doing. 👉 New Facebook Page: https://www.facebook.com/purserwellness Purser Wellness Root-Cause Medicine • Genetics • Homocysteine Research danpursermd.com #DrDanPurser #PurserWellness #Homocysteine #FunctionalMedicine #RootCauseHealth #CytokineResearch #ASD #ADHD #MTHFR

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FacebookJun 1, 2026

What if the biggest breakthroughs in autism support aren’t coming from symptom management alone?

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What if the biggest breakthroughs in autism support aren’t coming from symptom management alone? In our latest article, we dive deep into what we’ve seen consistently in practice: how genetic variants (especially MTHFR and related SNPs) ca

YouTubeMay 30, 2026

Autism Answered - Root Cause Solved with #1 Reviewed MD in the USA

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Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.

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FacebookMay 1, 2026

What if one tiny genetic variation could quietly influence how your body detoxifies, processes nutrients, and even…

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What if one tiny genetic variation could quietly influence how your body detoxifies, processes nutrients, and even supports your mental health—and most people have never heard of it? MTHFR isn’t just another health buzzword. It’s a conversa

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YouTubeApr 29, 2026

How to Properly Treat Kids: Root Cause Medicine for Autism, ADHD, and Developmental Challenges

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In this powerful live session, Dr. Dan Purser MD reveals why conventional pediatric medicine often falls short and shares his proven Purser Method® for helping children with autism spectrum traits, severe ADHD, chronic inflammation, and developmental delays. Drawing from over 43 years of clinical experience, Dr. Purser explains: Why genetic testing (especially MTHFR and related SNPs) is the essential first step How to use targeted, active-form nutrients instead of generic vitamins The role of leucovorin (high-dose folinic acid) and when it makes a real difference Practical ways to reduce toxin load and calm the inflammatory response Smart strategies around vaccination and detoxification support Dr. Purser emphasizes that kids are not little adults — their developing systems need precise, individualized care. Parents and practitioners will walk away with actionable steps that address root causes rather than just managing symptoms. Whether your child is struggling with speech delays, meltdowns, focus issues, or recurrent health problems, this episode offers real hope through biochemistry done right. Resources Mentioned: Pediatric MTHFR formulas: https://www.PhysicianDesigned.com Book a consultation: http://www.DanPurserMD.com Dr. Purser’s books on Amazon: https://www.amazon.com/-/e/B00BIKSGVQ If you’re a parent tired of “there’s nothing more we can do,” or a practitioner looking for better tools, this episode is for you. Timestamps available in the full video. Subscribe, leave a review, and share this with any parent who needs to hear it. The kids deserve better answers. Dan Purser MD – Root Cause Inflammation & Genetic Optimization #MTHFR #Autism #ADHD #ChildrensHealth #Leucovorin #FunctionalMedicine #Pediatrics Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

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SubstackMar 2, 2026

Can Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High Homocysteine May Be Doing to Your Arteries, Kidneys, and Fertility

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The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

YouTubeMar 2, 2026

Can Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High H

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The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step https://danpursermd.substack.com/p/can-glutathione-reverse-kidney-disease?utm_source=youtube

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YouTubeFeb 16, 2026

Signs That You Have High Copper Levels

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Follow Dr. Purser! Are you struggling with unexplained fatigue, muscle pain, or brain fog? High copper levels could be the hidden culprit—and fibromyalgia could be the diagnosis. Learn the key signs to watch for and how to take control of your health. #insulin #genetics #vitamins #Vars #wellness #PEMT #inflammation #glutathione #MicronutrientTesting #FunctionalMedicine #SOD #Homocysteine #ChronicInflammation #MethylationMatters #FunctionalWellness #GeneticTesting #NutrientDeficiency #MTHFR #fibromyalgia #Methylation #DrDanPurser #PurserWellness Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

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YouTubeJan 6, 2026

How To Know If You Have High Homocysteine?

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High homocysteine often shows up first as widespread inflammation—pain all over, poor circulation, or even early warning signs of cardiovascular problems like stroke and heart attack. The best way to know for sure is through testing: a blood test can measure homocysteine directly, while a CMA with Redox uncovers the vitamin deficiencies driving it. For genetic causes, the DRP Genetics panel screens 15–16 of the 17 known SNPs that can cause permanently high homocysteine. If your levels are fixed by genetics, reduced glutathione and targeted B vitamins (like MTHFR Daily) are key to balancing the

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