Let’s explore “Immunoglobulin M — lab reference”

CD40LG encodes CD40 ligand, which binds CD40 and supports communication needed for effective antibody responses. It is on the X chromosome, which changes how some genetic results must be interpreted. Also called: The ligand that helps acti…

PURSER WELLNESSNatural Support for Pain Management
From the reading room

Natural Support for Pain Management Chronic pain is a common and complex problem affecting 20–30% of the population of Western countries. The pharmaceutical industry has garnered billions of dollars in painkiller and anti-inflammatory sales…

TOP 10+ IDEAS TO IMPROVE YOUR INTERSTITIAL CYSTITIS (IC) I deal with root cause illnesses all day every day now for 35 years in practice. After advising several hundred patients with IC, I believe there is no way to cure it — mainly becaus…

Most doctors run standard serum blood tests, see a "normal" nutrient level, and send you home. But measuring floating nutrients in your liquid serum is like looking at the paint on a house to see if the plumbing works inside. After reviewing over 40,000 advanced intracellular vitamin lab panels, the truth is clear: intracellular glutathione vs serum levels tell two entirely different stories. Your serum can look completely fine while your cells are completely depleted of the master antioxidant needed to protect your life. The Cytokine Threat When methylation breaks down and homocysteine elevat

The older Purser genetics reference uses the heading “DAOA (AOC1)” in its gut section.

Explore interleukin-4, Th2 cells, immunoglobulin E (IgE), and allergic and atopic conditions.

PURSER WELLNESSMTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving SweetsA conversation with Dr. Purser

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

What if the answers you've been searching for aren't found in another prescription—but inside your own cells? Most lab tests tell you what's circulating in your blood. But what if your cells are telling a different story? A Cellular Micro

PURSER WELLNESSAutism Answered - Root Cause Solved with #1 Reviewed MD in the USAA conversation with Dr. Purser

Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.

If you haven't already, make sure to give me a follow in Youtube too! My team put together this great ORGANIZED page of many of my top topics. This is way better for quickly finding my videos on PCOS, Gut Health, Inflammation, POTs and SO M

PURSER WELLNESSRoot Cause Medicine - What is it?A conversation with Dr. Purser

For those who think I’m “alternative” or “on the edge,” let me clarify: I’m a Western-trained physician focused on root causes. I dive into genetics and vitamin deficiencies because they are grounded in science. Using intracellular vitamin panels and the latest research, I identify deficiencies and address them with the right versions of supplements. I love what I do and am here to help! Read my reviews, and thank you for trusting me.

Happy Halloween from me and Denise! 🎃👻 Denise is rocking Snow White while I’m channeling my inner cowboy, but the real magic happens when you book a CMA Consult with me. That’s the ultimate trick-or-treat for your health—no sugar crash, ju