…acid findings and the person’s medication history are relevant parts of that discussion.
Putting the pieces together
When you review a GAD1 result, your clinician may also look at B vitamins, magnesium, inositol, amino acids, fatty acids, a…
…mate. GAD1 does a related job, but the two genes are different. Check the exact name and variant on your report.
Putting the pieces together
When you review a GAD2 result, your clinician may also look at B vitamins, magnesium, inositol, ami…
GCLC helps make glutathione, an antioxidant your body produces.
Also called: Glutamate-Cysteine Ligase Catalytic Subunit
Making glutathione is a process
Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLC supplies the c…
… a process
Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLM supplies the modifier component that helps regulate that same glutathione-synthesis enzyme. This is different from enzymes that use glutathione after it has…
GDF5 encodes growth differentiation factor 5, a signaling protein involved in skeletal development, joint formation and cartilage biology. Its name does not mean a SNP measures the ability to build muscle.
Also called: Growth Differentiatio…
…ndling and helps explain why folate metabolism includes retention and processing as well as intake.
Also called: Gamma-Glutamyl Hydrolase
Managing folate inside cells
GGH encodes gamma-glutamyl hydrolase, which removes glutamate residues fr…
…s the glutathione peroxidase family alongside selenium and antioxidant support. GPX1 helps illustrate cellular peroxide handling. These enzymes use glutathione in peroxide reduction, so the presence of glutathione and the enzymes that use i…
…s the glutathione peroxidase family alongside selenium and antioxidant support. GPX3 helps illustrate extracellular peroxide defense. These enzymes use glutathione in peroxide reduction, so the presence of glutathione and the enzymes that u…
…s the glutathione peroxidase family alongside selenium and antioxidant support. GPX4 helps illustrate protection involving lipid peroxides in membranes. These enzymes use glutathione in peroxide reduction, so the presence of glutathione and…
…zed glutathione back to reduced glutathione, allowing this antioxidant system to be reused.
Also called: Glutathione Reductase
Recycling used glutathione
GSR encodes glutathione reductase. It uses reducing power from NADPH to help convert o…
… reactions involving particular compounds. This is a different part of the network from GCLC/GCLM, which help make glutathione, and GPX enzymes, which use it in peroxide defense.
Putting the pieces together
Dr. Purser’s course links this fa…
…Putting the pieces together
Dr. Purser places GSTO1 in his intracellular antioxidant teaching. The useful connection is between glutathione availability, oxidative workload and the larger detoxification network. A marker cannot identify a p…
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