THE PURSER WELLNESS ENCYCLOPEDIA
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What’s searchable?…e MTHFR step. Also called: Folate Hydrolase 1 Folate handling begins before remethylation Dr. Purser’s genetic chapters include FOLH1 in folate handling. The earlier genetics reference explains its role in breaking down polyglutamated food …
…nsport at the brain’s barriers. Blood folate and folate availability in the nervous system are not identical measurements. Also called: Folate Receptor 1 Folate transport has tissue-specific roles FOLR1 encodes folate receptor alpha, which …
FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier. Also called: Folate Receptor …
FTO is studied in relation to body weight and energy balance. Common variants can contribute to population-level differences in obesity susceptibility, alongside many other genes and environmental factors. Also called: Fat Mass and Obesity-…
FUT2 affects substances on the surfaces of the gut and other moist tissues and is studied in relation to the microbiome. Also called: Fucosyltransferase 2 The mucosal and microbiome connection Dr. Purser’s course places FUT2 in its gut–immu…
G6PC2 encodes a glucose-6-phosphatase-related protein expressed in pancreatic islet cells. Common variation is associated with differences in fasting glucose regulation; it is not the insulin receptor. Also called: Glucose-6-Phosphatase Cat…
GAD1 helps your body make GABA, a chemical messenger, from glutamate. Also called: Glutamate Decarboxylase 1 The glutamate-to-GABA connection Dr. Purser’s course uses GAD/GABA teaching to explain a connection between excitatory and inhibito…
GAD2 helps make GABA, a chemical messenger, from glutamate. Also called: Glutamate Decarboxylase 2 Another part of the GABA system GAD2 helps make GABA from glutamate. GAD1 does a related job, but the two genes are different. Check the exac…
GCLC helps make glutathione, an antioxidant your body produces. Also called: Glutamate-Cysteine Ligase Catalytic Subunit Making glutathione is a process Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLC supplies the c…
GCLM helps regulate one of the steps your body uses to make glutathione. Also called: Glutamate-Cysteine Ligase Modifier Subunit Making glutathione is a process Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLM suppli…
GDF5 encodes growth differentiation factor 5, a signaling protein involved in skeletal development, joint formation and cartilage biology. Its name does not mean a SNP measures the ability to build muscle. Also called: Growth Differentiatio…
GGH encodes gamma-glutamyl hydrolase, which removes glutamate residues from folate compounds. This affects folate handling and helps explain why folate metabolism includes retention and processing as well as intake. Also called: Gamma-Gluta…
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