THE PURSER WELLNESS ENCYCLOPEDIA

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Gene referenceSep 23, 2026

NR3C1

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NR3C1 encodes the glucocorticoid receptor, which helps tissues respond to cortisol and glucocorticoid medicines. Receptor genetics and measured cortisol levels answer different questions. Also called: Nuclear Receptor Subfamily 3 Group C Me…

Gene referenceSep 23, 2026

NR3C2

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NR3C2 encodes the mineralocorticoid receptor, which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor. Also called: Mineralocorticoid Receptor / Nuclear…

Gene referenceSep 23, 2026

NTRK2

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NTRK2 encodes TrkB, a receptor involved in responding to neurotrophic signals such as BDNF. These signals support nervous-system function and plasticity. NTRK2 is not a phosphatidylserine absorption transporter. Also called: Neurotrophic Re…

Gene referenceSep 23, 2026

PEMT

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Makes an enzyme involved in producing phosphatidylcholine, a component of cell membranes. Genetic findings alone do not establish a choline deficiency. Also called: Phosphatidylethanolamine N-Methyltransferase, choline, phosphatidylcholine …

Gene referenceSep 23, 2026

PON1

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PON1 is discussed in relation to how the body handles some compounds and protects certain fats. Also called: Paraoxonase 1 A different part of antioxidant handling PON1 appears in Dr. Purser’s redox and conversion teaching alongside GST and…

Gene referenceSep 23, 2026

PSEN1

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PSEN1 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis. Also called:…

Gene referenceSep 23, 2026

PSEN2

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PSEN2 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis. Also called:…

Gene referenceSep 23, 2026

PTGS2

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PTGS2, commonly called COX-2, encodes an enzyme involved in prostaglandin production. Prostaglandins participate in pain, fever and inflammatory signaling. Also called: COX2, Cyclooxygenase 2 COX-2 and inflammatory prostaglandins PTGS2, com…

Gene referenceSep 23, 2026

SERPINE1

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SERPINE1 makes PAI-1, a protein involved in breaking down blood clots. You may also see PAI4G used for this pathway. Also called: PAI-1, PAI4G, Plasminogen Activator Inhibitor-1, Plasminogen Activator Inhibitor 1, 4G/5G Polymorphism Balanci…

Gene referenceSep 23, 2026

SHMT1

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SHMT1 connects serine and glycine with folate chemistry. Also called: Serine Hydroxymethyltransferase 1 Where amino acids meet folate SHMT1 connects serine and glycine with folate pathways. That is one reason both nutrition and genetics can…

Gene referenceSep 23, 2026

SOD1

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SOD1 helps convert superoxide inside cells as part of the body’s antioxidant defenses. Also called: Superoxide Dismutase 1 Superoxide defense in its own setting Dr. Purser teaches SOD as one member of an antioxidant team. SOD1 works primari…

Gene referenceSep 23, 2026

SOD2

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SOD2 works in mitochondria as part of the body’s antioxidant defenses. Also called: Superoxide Dismutase 2 Superoxide defense in its own setting Dr. Purser teaches SOD as one member of an antioxidant team. SOD2 works in mitochondria and use…

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