…of glutathione S-transferases. These enzymes participate in redox chemistry, with roles that differ from the better-known GSTM1 and GSTP1 pathways.
Also called: Glutathione S-Transferase Omega 1
An omega-family glutathione enzyme
GSTO1 belo…
…linicians to compare the gene pattern with current nutrient/redox findings and tolerance. It explicitly avoids describing a person as unable to detox. Different GST genes and different variants should not be assumed to have identical effect…
…linicians to compare the gene pattern with current nutrient/redox findings and tolerance. It explicitly avoids describing a person as unable to detox. Different GST genes and different variants should not be assumed to have identical effect…
… receive histamine signals.
Putting the pieces together
The reference discusses dietary patterns and clinician-selected antihistamine approaches in this section. These are different mechanisms, not a recommendation to combine treatments fro…
… an HLA-DQ protein that presents antigen fragments to CD4 T cells. HLA-DQ function depends on pairing with an HLA-DQB chain, so an isolated marker is not a complete HLA type.
Also called: HLADQA1, Human Leukocyte Antigen DQA1
Antigen presen…
…eptor H1
Receiving the histamine signal
The Purser genetics reference places HRH1 in the histamine-response part of the MCAS discussion. H1 receptors help mediate histamine effects; they are not the enzymes that make histamine or break it d…
…stamine also connects to stomach acid
Dr. Purser’s genetics reference connects HRH2 with histamine signaling and gastric acid secretion. H2 is a receptor, so this teaching concerns response to a signal rather than histamine production by HD…
…ing and gut immune activation. The receptor gene and a measured cytokine level are different kinds of information; a receptor variant does not tell you how much IL-23 is circulating.
More from the teaching: Putting the pieces together
Immun…
…nd connects inflammatory workload with his homocysteine and redox framework. IL6 variation, a measured IL-6 concentration and a diagnosis of inflammatory disease are three different kinds of information. IL6R adds the receptor side of the s…
… break down some chemical messengers. A gene result cannot predict a mood or behavior.
Also called: MAO-A, Monoamine Oxidase A
Neurotransmitter breakdown in context
Dr. Purser places MAOA in the neurotransmitter-breakdown part of his brain-…
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