THE TEACHING CONNECTION
The receptor side of the IL-23 pathway
The receptor side of the IL-23 pathway
IL23R encodes part of the receptor that receives IL-23 signals. This connects the gene to the maintenance of Th17-related immune responses, which differ from the Th2 patterns discussed in allergy.
Putting the pieces together
Dr. Purser includes IL23R in his inflammatory bowel disease and psoriasis teaching. The gene, the cytokine IL-23 and the downstream cytokine IL-17A are related but distinct. An inherited marker does not measure receptor function in your tissues or diagnose either condition.
More from the teaching: A receptor in the gut–immune conversation
Dr. Purser’s course connects IL23R with IL-23 signaling and gut immune activation. The receptor gene and a measured cytokine level are different kinds of information; a receptor variant does not tell you how much IL-23 is circulating.
Putting the pieces together
Immune signals can be discussed alongside homocysteine and antioxidant defenses. Track when symptoms flare and what may trigger them, then review any measured results with your clinician. A single variant or cytokine result cannot diagnose an autoimmune disease or a cytokine storm.
Where the VARS Triad and MTHFR Daily fit
If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.
A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.
A question to bring to your visit
Do symptoms and standard clinical testing support the inflammatory condition being discussed?
Variant lookup
These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.
Names you may see
IL-23R · Interleukin 23 Receptor
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
Dr. Purser discusses these supplements in relation to IL23R.
Some genetic results may make these options more relevant to you. Review your full genetic report with your clinician before choosing a supplement.
CAPSULES & LIQUID
Glutathione options
SUPPLEMENT OPTIONS
VARS SOD
SUPPLEMENT OPTIONS
IL23R supplement options
SUPPLEMENT OPTIONS
VARS Catalase Support
See more supplement options
COMPARE YOUR OPTIONS
Methylation support
Explore supplements Dr. Purser discusses alongside inflammation and antioxidant support.
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your results can help your clinician choose between them.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
