THE PURSER WELLNESS ENCYCLOPEDIA

Let’s explore “Hashimoto’s thyroiditis and cytokines”

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Gene referenceSep 23, 2026

IL23R

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IL23R encodes part of the receptor that receives IL-23 signals. This connects the gene to the maintenance of Th17-related immune responses, which differ from the Th2 patterns discussed in allergy. Also called: IL-23R, Interleukin 23 Recepto…

Gene referenceSep 23, 2026

IL6

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IL6 encodes interleukin-6, a cytokine involved in immune responses and acute-phase signaling. It can appear in discussions of infection, chronic inflammation and metabolic health, with effects that depend on the context. Also called: IL-6, …

Gene referenceSep 23, 2026

MAOA

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MAOA helps break down some chemical messengers. A gene result cannot predict a mood or behavior. Also called: MAO-A, Monoamine Oxidase A Neurotransmitter breakdown in context Dr. Purser places MAOA in the neurotransmitter-breakdown part of …

Gene referenceSep 23, 2026

MTR

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Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine. Also called: Methionine Synthase The B12-dependent step In Dr. Purser’s teaching map, MTR is the B12-dependent step that converts …

Gene referenceSep 23, 2026

PEMT

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Makes an enzyme involved in producing phosphatidylcholine, a component of cell membranes. Genetic findings alone do not establish a choline deficiency. Also called: Phosphatidylethanolamine N-Methyltransferase, choline, phosphatidylcholine …

Gene referenceSep 23, 2026

PON1

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PON1 is discussed in relation to how the body handles some compounds and protects certain fats. Also called: Paraoxonase 1 A different part of antioxidant handling PON1 appears in Dr. Purser’s redox and conversion teaching alongside GST and…

Gene referenceSep 23, 2026

TCN2

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TCN2 helps carry vitamin B12 in the body. A gene result alone cannot tell you your B12 status. Also called: Transcobalamin II B12 must be carried as well as consumed TCN2 appears in Dr. Purser’s homocysteine and methylation map because it c…

Gene referenceSep 23, 2026

SLC19A1

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Encodes the reduced folate carrier, a protein involved in transporting folates into cells. Also called: RFC1, reduced folate carrier, folate transport Folate transport is part of the story Dr. Purser’s folate map includes transport as well …

Gene referenceSep 23, 2026

CCL3

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CCL3 encodes MIP-1 alpha, a chemokine involved in attracting and activating immune cells. It is related to CCL4, or MIP-1 beta, but the two genes and proteins are distinct. Also called: MIP-1 alpha and the chemokine cluster CCL3 encodes MI…

Gene referenceSep 23, 2026

CD40LG

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CD40LG encodes CD40 ligand, which binds CD40 and supports communication needed for effective antibody responses. It is on the X chromosome, which changes how some genetic results must be interpreted. Also called: The ligand that helps acti…

Gene referenceSep 23, 2026

IL16

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IL16 encodes interleukin-16, a cytokine involved in attracting and influencing immune cells, including CD4-expressing cells. Its recruitment role helps separate it from other numbered interleukins. Also called: A cytokine involved in immun…

Gene referenceSep 23, 2026

IL18

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IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP. Also called: An inflammatory signal that connects to int…

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