THE PURSER WELLNESS ENCYCLOPEDIA
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What’s searchable?…e involved in defense at tissue barriers and inflammatory signaling. It belongs to the Th17 pathway, which is supported by signals including IL-23. Also called: Th17 signaling and persistent inflammation IL17A encodes interleukin-17A, a cy…
…odes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP. Also called: An inflammatory signal that connects to interferon …
…ks with an accessory component, IL18RAP, to support IL-18 signaling. Also called: The binding side of the IL-18 receptor IL18R1 encodes a component of the receptor for IL-18. It works with an accessory component, IL18RAP, to support IL-18 …
…eeds coordinated components to translate an extracellular signal into a cellular response. Also called: The accessory component of IL-18 signaling IL18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coord…
…ry responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of having a common SNP. Also called: IL-1β and the early inflammatory response IL1B encodes interleukin-1 beta, a cytokine invo…
IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting. Also called: Barrier defense, repair and excess tissue gr…
IL23A encodes the p19 subunit of interleukin-23. Together with the p40 subunit encoded by IL12B, it forms a cytokine involved in supporting Th17 responses. Also called: The p19 component of IL-23 IL23A encodes the p19 subunit of interleuki…
IL2RA encodes the alpha chain of the interleukin-2 receptor, also called CD25. It is involved in immune activation and regulatory T-cell biology; a soluble receptor measurement is distinct from a DNA result. Also called: CD25 and immune-ce…
IL4 encodes interleukin-4, a cytokine involved in Th2 immune responses and antibody class switching, including pathways related to IgE. It operates alongside IL-5 and IL-13 rather than representing all allergic biology by itself. Also calle…
…5 encodes interleukin-5, a cytokine important to eosinophil growth, survival and activation. Eosinophils are involved in selected allergic and other inflammatory conditions. Also called: An eosinophil-focused cytokine IL5 encodes interleuk…
…nd and soluble receptor pathways help explain why IL-6 biology involves more than the amount of cytokine in a single blood sample. Also called: Receiving and relaying the IL-6 signal IL6R encodes the interleukin-6 receptor. Membrane-bound …
…thylfolate. Also called: Folinic acid has its own processing step MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR…
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