THE PURSER WELLNESS ENCYCLOPEDIA

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Gene referenceSep 23, 2026

HDC

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… receive histamine signals. Putting the pieces together The reference discusses dietary patterns and clinician-selected antihistamine approaches in this section. These are different mechanisms, not a recommendation to combine treatments fro…

Gene referenceSep 23, 2026

HLA-DQA1

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… an HLA-DQ protein that presents antigen fragments to CD4 T cells. HLA-DQ function depends on pairing with an HLA-DQB chain, so an isolated marker is not a complete HLA type. Also called: HLADQA1, Human Leukocyte Antigen DQA1 Antigen presen…

Gene referenceSep 23, 2026

HRH1

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…eptor H1 Receiving the histamine signal The Purser genetics reference places HRH1 in the histamine-response part of the MCAS discussion. H1 receptors help mediate histamine effects; they are not the enzymes that make histamine or break it d…

Gene referenceSep 23, 2026

HRH2

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…stamine also connects to stomach acid Dr. Purser’s genetics reference connects HRH2 with histamine signaling and gastric acid secretion. H2 is a receptor, so this teaching concerns response to a signal rather than histamine production by HD…

Gene referenceSep 23, 2026

IL23R

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…ing and gut immune activation. The receptor gene and a measured cytokine level are different kinds of information; a receptor variant does not tell you how much IL-23 is circulating. More from the teaching: Putting the pieces together Immun…

Gene referenceSep 23, 2026

MAOA

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… break down some chemical messengers. A gene result cannot predict a mood or behavior. Also called: MAO-A, Monoamine Oxidase A Neurotransmitter breakdown in context Dr. Purser places MAOA in the neurotransmitter-breakdown part of his brain-…

Gene referenceSep 23, 2026

MMP3

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… an enzyme involved in breaking down components of the extracellular matrix. Controlled remodeling is part of repair, while excess activity can accompany inflammatory tissue damage. Also called: Matrix Metallopeptidase 3 Remodeling the tiss…

Gene referenceSep 23, 2026

MTHFD1

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…oose a supplement dose for you. Variant IDs in the teaching reference: rs1076991, rs2236225 Where the VARS Triad and MTHFR Daily fit If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS…

Gene referenceSep 23, 2026

MTHFD1L

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…ing the pieces together Follow the connection to folate availability and the cellular processes that use one-carbon units. The pathway provides context, but it cannot tell you from the gene name alone whether homocysteine is elevated or how…

Gene referenceSep 23, 2026

MTHFR

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…re MTHFR deficiency. Also called: Methylenetetrahydrofolate Reductase, C677T, A1298C, folate, homocysteine Follow the pathway beyond MTHFR Dr. Purser teaches MTHFR within a larger folate and homocysteine pathway. MTHFR contributes to produc…

Gene referenceSep 23, 2026

MTR

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… status, folate status and current homocysteine been considered together? Reading your own results Bring your original report, current results, health history, and medicines to your visit. This information can help you ask questions, but it…

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