Let’s explore “Blood-vessel health: genetics, metabolism, and measured risk”

PURSER WELLNESSWhy We Use the VARS Triad: Glutathione, SOD & Catalase Working TogetherA conversation with Dr. Purser

New public listing. Open the original source for the full discussion.

An enzyme the body makes that breaks down hydrogen peroxide.

A molecule made from glutamate, cysteine and glycine that participates in cellular redox balance.

An amino acid used in protein synthesis and other metabolic processes.

The genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH).

ATG16L1 is involved in autophagy, a process that helps cells recycle parts.

CBS helps move homocysteine into the pathway that supplies building blocks for glutathione.

CHDH helps convert choline toward betaine, a nutrient involved in the homocysteine pathway.

COL5A1 encodes one component of type V collagen, which helps organize collagen fibers. It connects to the strength and structure of tendons, skin and other connective tissues.

Makes an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance.

CTH helps make cysteine, one of the building blocks your body uses to make glutathione.

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.