Let’s explore “IL-6 and IL-6R: the messenger and its receptor”

VKORC1 encodes vitamin K epoxide reductase, part of the vitamin K recycling system used in activating clotting proteins. It is not simply a vitamin K receptor.

CXCR5 encodes the receptor for CXCL13. This receptor helps guide B cells and certain T cells toward locations where organized immune responses develop.

DDAH1 encodes an enzyme that breaks down asymmetric dimethylarginine, or ADMA. ADMA inhibits nitric oxide synthase; DDAH1 is part of its clearance system, not the inhibitor itself.

IL15RA encodes the alpha receptor component for IL-15. It helps present IL-15 to responding immune cells, supporting communication that is important for particular lymphocyte populations.

IL18R1 encodes a component of the receptor for IL-18. It works with an accessory component, IL18RAP, to support IL-18 signaling.

IL18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coordinated components to translate an extracellular signal into a cellular response.

IL2RA encodes the alpha chain of the interleukin-2 receptor, also called CD25. It is involved in immune activation and regulatory T-cell biology; a soluble receptor measurement is distinct from a DNA result.

TGFB1 encodes transforming growth factor beta 1, which has roles in immune regulation, tissue repair and extracellular-matrix production. Its effects can include both regulation of inflammation and promotion of fibrosis.

ADRB2 is the gene name for Beta-2 Adrenergic Receptor. Learn what a specific result could mean and what to ask about it.

CCR3 is the gene name for C-C Motif Chemokine Receptor 3. Learn what a specific result could mean and what to ask about it.

Encodes cubilin, part of a receptor system involved in uptake of the intrinsic-factor–B12 complex.

ESR2 is the gene name for Estrogen Receptor 2. Learn what a specific result could mean and what to ask about it.